Tenofovir nephrotoxicity: 2011 update
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
HindawiDate
2011-12-01Citation
10.1155/2011/354908
AIDS Researched and Treatment 2011 (2011): 354908
ISSN
2090-1240 (print); 2090-1259 (online)DOI
10.1155/2011/354908Funded by
The following are the grant numbers and sources of support received by the authors: FIS PS09/00447, PI081564, ISCIIIRETIC REDinREN/RD06/0003, REDinREN/RD06/0004, Fondecyt 1080083. Comunidad de Madrid/FRACM/S-BIO- 0283/2006, SAF 2007/63648 y CAMS-GEN-0247/2006. SEN, IRSIN; Salary support: FIS to M. D. Sanchez Ni no, A. B. Sanz, B. Fernandez- Fernandez (Rio Hortega), Programa Intensificación Actividad Investigadora (ISCIII/Agencia La´ın-Entralgo/CM) to AO.Project
Comunidad de Madrid. S2010/BMD-2378/CIFRA; Comunidad de Madrid. S2006/BIO-0283/FRACM; Comunidad de Madrid. S2006/GEN-0247/PROTEOMARKERS-CMEditor's Version
http://dx.doi.org/10.1155/2011/354908Subjects
Tenofovir; Kidney; MedicinaRights
© 2011 Beatriz Fernandez-Fernandez et al.Abstract
Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir
and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell
culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit significant,
risk of kidney injury. Proximal tubular cell secretion of tenofovir explains the accumulation of the drug in these mitochondriarich
cells. Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney
injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial.
Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serumcreatinine in
high-risk patients is required tominimize nephrotoxicity. Newer, structurally similarmolecular derivatives that do not accumulate
in proximal tubules are under study.
Files in this item
Google Scholar:Fernández-Fernández, Beatriz
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Montoya-Ferrer, Ana
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Sanz, Ana Belén
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Sánchez Niño, María Dolores
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Izquierdo, María C.
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Poveda, Jonay
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Sainz-Prestel, Valeria
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Ortíz-Martín, Natalia
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Parra-Rodríguez, Alejandro
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Selgas, Rafael
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Ruiz Ortega, Marta
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Egido, Jesús
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Ortiz Arduán, Alberto
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