Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Tyrosine phosphorylation modulates the vascular responses of mesenteric arteries from human colorectal tumors
Entity
UAM. Departamento de FisiologíaPublisher
Hindawi Publishing CorporationDate
2013-12-16Citation
10.1155/2013/545983
BioMed Research International 2014 (2014): 545983
ISSN
2314-6133 (print); 2314-6141 (online)DOI
10.1155/2013/545983Funded by
This work was financed by Fondo de Investigaciones Sanitarias (PS09/00394) and Fundaci´on Mutua Madrileña (AP57242009)Editor's Version
http://dx.doi.org/10.1155/2013/545983Subjects
Tyrosine phosphorylation; MedicinaRights
Copyright © 2013 Eduardo Ferrero et al.Abstract
The aim of this study was to analyze whether tyrosine phosphorylation in tumoral arteries may modulate their vascular response.
To do this, mesenteric arteries supplying blood flow to colorectal tumors or to normal intestine were obtained during surgery and
prepared for isometric tension recording in an organ bath. Increasing tyrosine phosphorylation with the phosphatase inhibitor,
sodium orthovanadate produced arterial contraction which was lower in tumoral than in control arteries, whereas it reduced the
contraction to noradrenaline in tumoral but not in control arteries and reduced the relaxation to bradykinin in control but not
in tumoral arteries. Protein expression of VEGF-A and of the VEGF receptor FLT1 was similar in control and tumoral arteries,
but expression of the VEGF receptor KDR was increased in tumoral compared with control arteries. This suggests that tyrosine
phosphorylation may produce inhibition of the contraction in tumoral mesenteric arteries, which may increase blood flow to the
tumor when tyrosine phosphorylation is increased by stimulation of VEGF receptors
Files in this item
Google Scholar:Ferrero, Eduardo H.
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Mauricio, María Dolores
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Granado García, Miriam
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García-Villar, Oscar
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Aldasoro, Martín
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Vilà, José María
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Hidalgo, Manuel M.
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Ferrero, Jorge Luis
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Fernández Monsalve, Nuria
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Monge Sánchez, Luis
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García-Villalón, Ángel Luis
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