UAM_Biblioteca | Unified search engine | Scientific Production Portal | UAM Research Data Repository
Universidad Autónoma de Madrid
Biblos-e Archivo
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
    • español
    • English
  • English 
    • español
    • English
  • Log in
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search Biblos-e Archivo

Advanced Search

Browse

All of Biblos-e ArchivoCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultiesThis CollectionBy Issue DateAuthorsTitlesSubjectsFaculties

My Account

Log inRegister

Statistics

View Usage Statistics

Help

Information about Biblos-e ArchivoI want to submit my workI want to submit my doctoral thesisFrequently Asked QuestionsCopyrightsFinancial Agencies and OA policy

UAM_Biblioteca

View Item 
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item

Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis?

Author
Fernández Fernández, Beatriz; Ortiz Arduán, Albertountranslated; Gómez-Guerrero, Carmen; Barat, Antonio; Martín-Cleary, Catalina; Egido de los Ríos, Jesús
Entity
UAM. Departamento de Medicina
Publisher
BioMed Central
Date
2012-04-26
Citation
10.1186/1471-2369-13-21
BMC Nephrology 13 (2012): 21
 
 
 
ISSN
1471-2369
DOI
10.1186/1471-2369-13-21
Funded by
The authors have been supported by FIS PI 10/00072, PS09/00447, ISCIIIRETIC REDinREN RD06/0016, MICINN (SAF2009/11794), Eurosalud (EUS 2008/ 03565) FRIAT (Fundación Renal Iñigo Álvarez de Toledo) and Fundacion Lilly (JE).
Editor's Version
http://dx.doi.org/10.1186/1471-2369-13-21
Subjects
Angiotensin; Juxtaglomerular apparatus hyperplasia; Nephrotic syndrome; Paricalcitol; Renin; Medicina
URI
http://hdl.handle.net/10486/662163
Rights
© 2012 Fernandez-Fernandez et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Background: Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach. Our understanding on the molecular effects of dual blockade in humans is incomplete. Case presentation: We present a patient with corticoid resistant nephrotic syndrome who developed marked juxtaglomerular apparatus hyperplasia and renin expression in the context of dual angiotensin system blockade. Conclusions: Although renin may have profibrotic effects mediated by (pro)renin receptor activation, this report raises questions on the potential consequences of local renin activation on chronic kidney disease in patients with dual angiotensin blockade.
Show full item record

Files in this item

Thumbnail
Name
juxtaglomerular_fernandezfernandez_BMCN_2012.pdf
Size
473.8Kb
Format
PDF

Refworks Export

Delicious Save this on Delicious

Google™ Scholar:Fernández Fernández, Beatriz - Ortiz Arduán, Alberto - Gómez-Guerrero, Carmen - Barat, Antonio - Martín-Cleary, Catalina - Egido de los Ríos, Jesús

This item appears in the following Collection(s)

  • Producción científica en acceso abierto de la UAM [14744]

Related items

Showing items related by title, author, creator and subject.

  • Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? 

    Fernández-Fernández, Beatriz; Ortíz, Alberto; Gómez-Guerrero, Carmen; Barat, Antonio; Martín-Cleary, Catalina; Egido, Jesús
    2012-04-26
  • Horizon 2020 in diabetic kidney disease: The clinical trial pipeline for add-on therapies on Top of Renin Angiotensin System Blockade 

    Pérez-Gómez, María Vanessa; Sánchez-Niño, María Dolores; Sanz, Ana Belén; Martín-Cleary, Catalina; Ruiz-Ortega, Marta; Egido, Jesús; Navarro-González, Juan F.; Ortiz, Alberto; Fernández-Fernández, Beatriz
    2015-06-18
  • Aki associated with macroscopic glomerular hematuria: Clinical and pathophysiologic consequences 

    Moreno, Juan Antonio M; Martín-Cleary, Catalina; Gutiérrez, Eduardo; Toldos, Oscar; Blanco-Colio, Luís Miguel; Praga, Manuel; Ortiz Arduán, AlbertoAutoridad UAM; Egido, Jesús
    2012-01-01
All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
 

 

All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram