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Capecitabine and bevacizumab as first-line treatment in elderly patients with metastatic colorectal cancer

Author
Feliu Batlle, Jaime; Safont, María José; Salud, Antonieta T.; Losa, Ferrán C.; García-Girón, Carlos; Bosch, Carles J A; Escudero, Pilar; López Manzanera, Rafael; Madroñal, C.; Bolaños, Margarita; Gil, Mireia; Llombart, Antonio C.; Castro-Carpeño, J.; González Barón, Manuel
Entity
UAM. Departamento de Medicina
Publisher
Nature Publishing Group
Date
2010-05-01
Citation
10.1038/sj.bjc.6605663
British Journal of Cancer 102.10 (2010): 1468 – 1473
 
 
 
ISSN
0007-0920 (print); 1532-1827 (online)
DOI
10.1038/sj.bjc.6605663
Funded by
This study was supported by Hoffmann-La Roche, Nutley, NJ, USA.
Editor's Version
http://dx.doi.org/10.1038/sj.bjc.6605663
Subjects
Aged; Bevacizumab; Capecitabine; Colorectal neoplasms; Neoplasm metastasis; Medicina
URI
http://hdl.handle.net/10486/662397
Rights
© 2010 Cancer Research UK

Abstract

BACKGROUND: The efficacy and safety of capecitabine and bevacizumab in elderly patients with metastatic colorectal cancer (mCRC) considered unsuitable for receiving first-line chemotherapy with an irinotecan or oxaliplatin-based combination were assessed in a phase II, open, multicentre, uncontrolled study. METHODS: Treatment consisted of capecitabine 1250 mgm 2 (or 950 mgm 2 for patients with a creatinine clearance of 30–50ml min 1) twice daily on days 1–14 and bevacizumab (7.5 mg kg 1) on day 1 every 3 weeks. RESULTS: A total of 59 patients aged X70 years with mCRC were enrolled. In an intention-to-treat analysis, the overall response rate was 34%, with 71% of patients achieving disease control. Median progression-free survival and overall survival were 10.8 months and 18 months, respectively. In all, 32 patients (54%) had grade 3/4 adverse events (AEs), the most common being hand–foot syndrome (19%), diarrhoea (9%) and deep venous thrombosis (7%). Four patients died because of treatment-related AEs. A relationship was detected between creatinine clearance p50 ml min 1 and the development of non-bevacizumab-related grade 3/4 AEs. The incidence of bevacizumab-associated AEs (hypertension, thromboembolic events and proteinuria) was consistent with that of previous reports in elderly patients. CONCLUSION: Bevacizumab combined with capecitabine represents a valid therapeutic alternative in elderly patients considered to be unsuitable for receiving polychemotherapy.
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Google™ Scholar:Feliu Batlle, Jaime - Safont, María José - Salud, Antonieta T. - Losa, Ferrán C. - García-Girón, Carlos - Bosch, Carles J A - Escudero, Pilar - López Manzanera, Rafael - Madroñal, C. - Bolaños, Margarita - Gil, Mireia - Llombart, Antonio C. - Castro-Carpeño, J. - González Barón, Manuel

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  • Producción científica en acceso abierto de la UAM [14677]

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