Hypertensive effects of the iv administration of picomoles of ouabain
EntityUAM. Departamento de Farmacología
PublisherAssociação Brasileira de Divulgação Científica
10.1590/S0100-879X2011007500103Brazilian Journal of Medical and Biological Research 44.9 ( (2011): 933-938
Funded byResearch supported by CNPq, CAPES, FAPES/ FUNCITEC (#SAF2009 02376) and MCIIN (#SAF2009 02376) and Banco Santader.
SubjectsHypertension; Ouabain; Renin-angiotensin system; Vascular reactivity; Farmacia; Medicina
Rights© A.S. Padilha et al.
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for this association is that ouabain binds to the α-subunit of the Na+ pump, inhibiting its activity. Inhibition of this pump increases intracellular Na+, which reduces the activity of the sarcolemmal Na+/Ca2+ exchanger and thereby reduces Ca2+ extrusion. Consequently, intracellular Ca2+ increases and is taken up by the sarcoplasmic reticulum, which, upon activation, releases more calcium and increases the vascular smooth muscle tone. In fact, acute treatment with ouabain enhances the vascular reactivity to vasopressor agents, increases the release of norepinephrine from the perivascular adrenergic nerve endings and promotes increases in the activity of endothelial angiotensin-converting enzyme and the local synthesis of angiotensin II in the tail vascular bed. Additionally, the hypertension induced by ouabain has been associated with central mechanisms that increase sympathetic tone, subsequent to the activation of the cerebral renin-angiotensin system. Thus, the association with peripheral mechanisms and central mechanisms, mainly involving the renin-angiotensin system, may contribute to the acute effects of ouabain-induced elevation of arterial blood pressure
Google Scholar:Padilha, Alessandra Simão - Salaices Sánchez, Mercedes - Vassallo, Dalton Valentim - Batista, Priscila Rossi - Siman, Fabiana Dayse Magalhães
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