MicroRNA signatures in B-cell lymphomas
Entity
UAM. Departamento de Anatomía PatológicaPublisher
Nature PublishingDate
2012-03-01Citation
10.1038/bcj.2012.1
Blood Cancer Journal 2 (2012): e57
ISSN
2044-5385DOI
10.1038/bcj.2012.1Funded by
This work was supported by grants from the AECC, Fondo de Investigaciones Sanitarias (RETICS, PI051623, PI052800); (FI08/00038, LDL), (CP06/00002; NM); the Ministerio de Ciencia e Innovación (SAF2008-03871, SAF2007-65957-C02-02), Fundación la Caixa and the National Institute of Bioinformatics (GGL), Spain.Editor's Version
http://doi.org/10.1038/bcj.2012.1Subjects
B-cell lymphoma; Lymphoma diagnosis; Microarray; microRNA; miRNA expression profile; MedicinaRights
© 2012 Macmillan Publishers Limited. All rights reserved 2044-5385/12Abstract
Accurate lymphoma diagnosis, prognosis and therapy still require additional markers. We explore the potential relevance of
microRNA (miRNA) expression in a large series that included all major B-cell non-Hodgkin lymphoma (NHL) types. The data
generated were also used to identify miRNAs differentially expressed in Burkitt lymphoma (BL) and diffuse large B-cell
lymphoma (DLBCL) samples. A series of 147 NHL samples and 15 controls were hybridized on a human miRNA one-color
platform containing probes for 470 human miRNAs. Each lymphoma type was compared against the entire set of NHLs. BL was
also directly compared with DLBCL, and 43 preselected miRNAs were analyzed in a new series of routinely processed samples
of 28 BLs and 43 DLBCLs using quantitative reverse transcription-polymerase chain reaction. A signature of 128 miRNAs
enabled the characterization of lymphoma neoplasms, reflecting the lymphoma type, cell of origin and/or discrete oncogene
alterations. Comparative analysis of BL and DLBCL yielded 19 differentially expressed miRNAs, which were confirmed in a
second confirmation series of 71 paraffin-embedded samples. The set of differentially expressed miRNAs found here expands
the range of potential diagnostic markers for lymphoma diagnosis, especially when differential diagnosis of BL and DLBCL
is required.
Files in this item
Google Scholar:Di Lisio, Lorena
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Sánchez-Beato, Margarita
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Gómez López, Gonzalo
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Rodríguez, María Eugenia
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Montes-Moreno, Santiago
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Mollejo, Manuela
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Menárguez, Javier
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Martínez Hernández, Miguel Ángel
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Alvés, Francisco J.
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Pisano, David G.
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Piris, Miguel Ángel
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Martínez, Nerea
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