MicroRNA signatures in B-cell lymphomas

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dc.contributor.author Di Lisio, Lorena
dc.contributor.author Sánchez-Beato, Margarita
dc.contributor.author Gómez-López, Gonzalo
dc.contributor.author Rodríguez, María Eugenia
dc.contributor.author Montes-Moreno, Santiago
dc.contributor.author Mollejo, Manuela
dc.contributor.author Menárguez, Javier
dc.contributor.author Martínez Hernández, Miguel Ángel
dc.contributor.author Alvés, Francisco J.
dc.contributor.author Pisano, David G.
dc.contributor.author Piris, Miguel Ángel
dc.contributor.author Martínez, Nerea
dc.contributor.other UAM. Departamento de Anatomía Patológica es_ES
dc.date.accessioned 2014-11-05T11:32:35Z
dc.date.available 2014-11-05T11:32:35Z
dc.date.issued 2012-03-01
dc.identifier.citation Blood Cancer Journal 2 (2012): e57 en_US
dc.identifier.issn 2044-5385 es_ES
dc.identifier.uri http://hdl.handle.net/10486/662411
dc.description.abstract Accurate lymphoma diagnosis, prognosis and therapy still require additional markers. We explore the potential relevance of microRNA (miRNA) expression in a large series that included all major B-cell non-Hodgkin lymphoma (NHL) types. The data generated were also used to identify miRNAs differentially expressed in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) samples. A series of 147 NHL samples and 15 controls were hybridized on a human miRNA one-color platform containing probes for 470 human miRNAs. Each lymphoma type was compared against the entire set of NHLs. BL was also directly compared with DLBCL, and 43 preselected miRNAs were analyzed in a new series of routinely processed samples of 28 BLs and 43 DLBCLs using quantitative reverse transcription-polymerase chain reaction. A signature of 128 miRNAs enabled the characterization of lymphoma neoplasms, reflecting the lymphoma type, cell of origin and/or discrete oncogene alterations. Comparative analysis of BL and DLBCL yielded 19 differentially expressed miRNAs, which were confirmed in a second confirmation series of 71 paraffin-embedded samples. The set of differentially expressed miRNAs found here expands the range of potential diagnostic markers for lymphoma diagnosis, especially when differential diagnosis of BL and DLBCL is required. en_US
dc.description.sponsorship This work was supported by grants from the AECC, Fondo de Investigaciones Sanitarias (RETICS, PI051623, PI052800); (FI08/00038, LDL), (CP06/00002; NM); the Ministerio de Ciencia e Innovación (SAF2008-03871, SAF2007-65957-C02-02), Fundación la Caixa and the National Institute of Bioinformatics (GGL), Spain. en_US
dc.format.extent 9 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Nature Publishing en_US
dc.relation.ispartof Blood Cancer Journal en_US
dc.rights © 2012 Macmillan Publishers Limited. All rights reserved 2044-5385/12 es_ES
dc.subject.other B-cell lymphoma en_US
dc.subject.other Lymphoma diagnosis en_US
dc.subject.other Microarray en_US
dc.subject.other microRNA en_US
dc.subject.other miRNA expression profile en_US
dc.title MicroRNA signatures in B-cell lymphomas en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://doi.org/10.1038/bcj.2012.1 es_ES
dc.identifier.doi 10.1038/bcj.2012.1 es_ES
dc.identifier.publicationfirstpage e57 es_ES
dc.identifier.publicationissue 2 es_ES
dc.identifier.publicationvolume 2 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en

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