Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study
Autor (es)
Alcaraz, A.; González-López, Raquel; Morote, J.; De La Piedra, Concepción; Meseguer, Cristina; Esteban, Emilio; Climent, Miguel Ángel; González-Gragera, B.; Álvarez-Ossorio, Jose Luis; Chirivella, Isabel; Mellado, Begoña; Lara, Pedro Carlos; Vázquez, Fernando Javier; Contreras Viedma, José Antonio; Carles, Joan; Murias, Adolfo; Calderero, Verónica; Comet-Batlle, Josep; González Del Alba, Aránzazu; León Mateos, Luis A.; Mañas, Ana; Segarra, José; Lassa, A.; González Enguita, María del Carmen; Méndez, Míriam J.; Samper, Pilar María; Unda, Miguel; Mahillo, Ignacio; Bellmunt, Joaquim; Alcaraz, A.; González-López, Raquel; Morote, J.; De La Piedra, Concepción; Meseguer, Cristina; Esteban, Emilio; Climent, Miguel Ángel; González-Gragera, B.; Álvarez-Ossorio, Jose Luis; Chirivella, Isabel; Mellado, Begoña; Lara, Pedro Carlos; Vázquez, Fernando Javier; Contreras, José Antonio Viedma; Carles, Joan; Murias, Adolfo; Calderero, Verónica; Comet-Batlle, Josep; González Del Alba, Aránzazu; León Mateos, Luis A.; Mañas, Ana; Segarra, José; Lassa, A.; González Enguita, María del Carmen; Méndez, Míriam J.; Samper, Pilar María; Unda, Miguel; Mahillo, Ignacio; Bellmunt, JoaquimEntidad
UAM. Departamento de CirugíaEditor
Cancer Research UKFecha de edición
2013-07-09Cita
10.1038/bjc.2013.272
British Journal of Cancer 109 (2013): 121–130
ISSN
0007-0920 (print); 1532-1827 (online)DOI
10.1038/bjc.2013.272Financiado por
Novartis Oncology Spain for supporting this studyVersión del editor
http://dx.doi.org/10.1038/bjc.2013.272Materias
Bladder cancer; Renal cell carcinoma; Bone markers; Overall survival; Disease progression; Skeletal-related events; MedicinaDerechos
© 2013 Cancer Research UK. All rights reserved 0007 – 0920/13Resumen
Background: Levels of bone turnover markers (BTM) might be correlated with outcome in terms of skeletal-related events (SRE),
disease progression, and death in patients with bladder cancer (BC) and renal cell carcinoma (RCC) with bone metastases (BM).
We try to evaluate this possible correlation in patients who receive treatment with zoledronic acid (ZOL).
Methods: This observational, prospective, and multicenter study analysed BTM and clinical outcome in these patients. Serum
levels of bone alkaline phosphatase (BALP), procollagen type I amino-terminal propeptide (PINP), and beta-isomer of carboxyterminal
telopeptide of type I collagen (b-CTX) were analysed.
Results: Patients with RCC who died or progressed had higher baseline b-CTX levels and those who experienced SRE during
follow-up showed high baseline BALP levels. In BC, a poor rate of survival was related with high baseline b-CTX and BALP levels,
and new SRE with increased PINP levels. Cox univariate analysis showed that b-CTX levels were associated with higher mortality
and disease progression in RCC and higher mortality in BC. Bone alkaline phosphatase was associated with increased risk of
premature SRE appearance in RCC and death in BC.
Conclusion: Beta-isomer of carboxy-terminal telopeptide of type I collagen and BALP can be considered a complementary tool
for prediction of clinical outcomes in patients with BC and RCC with BM treated with ZOL
Lista de ficheros
Google Scholar:Alcaraz, A.
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González-López, Raquel
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Morote, J.
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De La Piedra, Concepción
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Meseguer, Cristina
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Esteban, Emilio
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Climent, Miguel Ángel
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González-Gragera, B.
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Álvarez-Ossorio, Jose Luis
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Chirivella, Isabel
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Mellado, Begoña
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Lara, Pedro Carlos
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Vázquez, Fernando Javier
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Contreras Viedma, José Antonio
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Carles, Joan
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Murias, Adolfo
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Calderero, Verónica
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Comet-Batlle, Josep
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González Del Alba, Aránzazu
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León Mateos, Luis A.
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Mañas, Ana
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Segarra, José
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Lassa, A.
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González Enguita, María del Carmen
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Méndez, Míriam J.
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Samper, Pilar María
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Unda, Miguel
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Mahillo, Ignacio
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Bellmunt, Joaquim
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Alcaraz, A.
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González-López, Raquel
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Morote, J.
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De La Piedra, Concepción
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Meseguer, Cristina
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Esteban, Emilio
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Climent, Miguel Ángel
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González-Gragera, B.
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Álvarez-Ossorio, Jose Luis
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Chirivella, Isabel
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Mellado, Begoña
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Lara, Pedro Carlos
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Vázquez, Fernando Javier
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Contreras, José Antonio Viedma
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Carles, Joan
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Murias, Adolfo
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Calderero, Verónica
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Comet-Batlle, Josep
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González Del Alba, Aránzazu
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León Mateos, Luis A.
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Mañas, Ana
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Segarra, José
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Lassa, A.
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González Enguita, María del Carmen
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Méndez, Míriam J.
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Samper, Pilar María
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Unda, Miguel
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Mahillo, Ignacio
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Bellmunt, Joaquim
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