Polyunsaturated fatty acids in atrial fibrillation: Looking for the proper candidates
Entity
UAM. Departamento de MedicinaPublisher
FrontiersDate
2012Citation
10.3389/fphys.2012.00370
Frontiers in physiology 3 (2012): 370
ISSN
1664-042XDOI
10.3389/fphys.2012.00370Funded by
NHLBI Grant K99-HL105574 to SFN and the Alfonso Martín Escudero Foundation Grant to DFREditor's Version
http://dx.doi.org/10.3389/fphys.2012.00370Subjects
Atrial fibrillation; Drug therapy; Omega-3 polyunsaturated fatty acids; Prevention; Remodeling; MedicinaNote
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionRights
© 2012 Los autoresAbstract
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice
with growing prevalence in developed countries. Several medical and interventional
therapies, such as atrial specific drugs and pulmonary vein isolation, have demonstrated
prevention of recurrences. However, their suboptimal long-term success and significant
rate of secondary effects have led to intensive research in the last decade focused on
novel alternative and supplemental therapies. One such candidate is polyunsaturated fatty
acids (PUFAs). Because of their biological properties, safety, simplicity, and relatively cheap
cost, there is a special clinical interest in omega-3 PUFAs as a possible antiarrhythmic agent.
Obtained from diets rich in fish, they represent one of the current supplemental therapies.
At the cellular level, an increasing body of evidence has shown that n-3 PUFAs exert a
variety of effects on cardiac ion channels, membrane dynamic properties, inflammatory
cascade, and other targets related to AF prevention. In this article, we review the current
basic and clinical evidence pertinent to n-3 PUFAs in AF treatment and prevention.We also
discuss controversial outcomes among clinical studies and propose specific subsets of AF
patients who will benefit most from n-3 PUFAs
Files in this item
Google Scholar:Salvador Montañés, Oscar
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Gómez-Gallanti, Alfonso
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Garofalo, Daniel
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Noujaim, Sami F.
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Peinado Peinado, Rafael
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Filgueiras Rama, David
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