Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in Spain: The MERENA observational cohort study

Biblos-e Archivo/Manakin Repository

Show simple item record

dc.contributor.author Martínez-Castelao, Alberto M.
dc.contributor.author Górriz, José Luis
dc.contributor.author Portolés, José María
dc.contributor.author De Álvaro, Fernando
dc.contributor.author Cases, Aleix I.
dc.contributor.author Lũo, José
dc.contributor.author Navarro-González, Juan F.
dc.contributor.author Montes, Rafael
dc.contributor.author De La Cruz-Troca, Juan José
dc.contributor.author Natarajan, Aparna
dc.contributor.author Batlle, Daniel C.
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.date.accessioned 2015-01-08T16:04:59Z
dc.date.available 2015-01-08T16:04:59Z
dc.date.issued 2011-10-07
dc.identifier.citation BMC Nephrology 12 (2011): 53 en_US
dc.identifier.issn 1471-2369 es_ES
dc.identifier.uri http://hdl.handle.net/10486/663007
dc.description.abstract To obtain information on cardiovascular morbidity, hypertension control, anemia and mineral metabolism based on the analysis of the baseline characteristics of a large cohort of Spanish patients enrolled in an ongoing prospective, observational, multicenter study of patients with stages 3 and 4 chronic kidney diseases (CKD). Methods: Multicenter study from Spanish government hospital-based Nephrology outpatient clinics involving 1129 patients with CKD stages 3 (n = 434) and 4 (n = 695) defined by GFR calculated by the MDRD formula. Additional analysis was performed with GFR calculated using the CKD-EPI and Cockcroft-Gault formula. Results: In the cohort as a whole, median age 70.9 years, morbidity from all cardiovascular disease (CVD) was very high (39.1%). In CKD stage 4, CVD prevalence was higher than in stage 3 (42.2 vs 35.6% p < 0.024). Subdividing stage 3 in 3a and 3b and after adjusting for age, CVD increased with declining GFR with the hierarchy (stage 3a < stage 3b < stage 4) when calculated by CKD-EPI (31.8, 35.4, 42.1%, p 0.039) and Cockcroft-Gault formula (30.9, 35.6, 43.4%, p 0.010) and MDRD formula (32.5, 36.2, 42.2%,) but with the latter, it did not reach statistical significance (p 0.882). Hypertension was almost universal among those with stages 3 and 4 CKD (91.2% and 94.1%, respectively) despite the use of more than 3 anti-hypertensive agents including widespread use of RAS blockers. Proteinuria (> 300 mg/day) was present in more than 60% of patients and there was no significant differences between stages 3 and 4 CKD (1.2 ± 1.8 and 1.3 ± 1.8 g/day, respectively). A majority of the patients had hemoglobin levels greater than 11 g/dL (91.1 and 85.5% in stages 3 and 4 CKD respectively p < 0.001) while the use of erythropoiesisstimulating agents (ESA) was limited to 16 and 34.1% in stages 3 and 4 CKD respectively. Intact parathyroid hormone (i-PTH) was elevated in stage 3 and stage 4 CKD patients (121 ± 99 and 166 ± 125 pg/mL p 0.001) despite good control of calcium-phosphorus levels. Conclusion: This study provides an overview of key clinical parameters in patients with CKD Stages 3 and 4 where delivery or care was largely by nephrologists working in a network of hospital-based clinics of the Spanish National Healthcare System en_US
dc.format.extent 11 pag. en
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher BioMed Central en_US
dc.relation.ispartof BMC Nephrology en_US
dc.rights © 2011 Martínez-Castelao et al; licensee BioMed Central Ltd. en_US
dc.subject.other Cardiovascular morbidity en_US
dc.subject.other Hypertension control en_US
dc.subject.other Spain en_US
dc.title Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in Spain: The MERENA observational cohort study en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://www.biomedcentral.com/1471-2369/12/53 es_ES
dc.identifier.doi 10.1186/1471-2369-12-53 es_ES
dc.identifier.publicationfirstpage 53 es_ES
dc.identifier.publicationlastpage 53 es_ES
dc.identifier.publicationvolume 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Portoles Pérez, José María (262442)
dc.authorUAM De Álvaro Moreno, Fernando (261178)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record