Diagnostic potential of circulating cell-free DNA in patients needing mechanical ventilation: Promises and challenges

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dc.contributor.author Arnalich, Francisco M.
dc.contributor.author López-Collazo, Eduardo
dc.contributor.author Montiel, Carmen
dc.contributor.other UAM. Departamento de Farmacología es_ES
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.date.accessioned 2015-01-09T08:59:09Z
dc.date.available 2015-01-09T08:59:09Z
dc.date.issued 2011-09-12
dc.identifier.citation Critical Care 15 (2011):187 en_US
dc.identifier.issn 1364-8535 es_ES
dc.identifier.uri http://hdl.handle.net/10486/663013
dc.description.abstract Circulating cell-free DNA (cf-DNA) mainly comes from apoptotic cells and can refl ect the extent of cellular damage. Increased plasma levels of cf-DNA have been found in many acute disorders, including septic and clinically ill patients, and usually correlate well with clinical outcome. Acute respiratory failure, the most frequent organ failure in ICU patients, can be related to various acute diseases that may cause cell death and release of DNA into the bloodstream. In a recent issue of Critical Care, Okkonen and colleagues evaluate levels of cf-DNA in plasma as a prognostic marker in patients needing mechanical ventilation. They report that plasma cf-DNA was higher than normal in patients with mechanical ventilation, and even higher in patients who eventually died compared to survivors. However, its usefulness as a death predictor may be limited in the heterogeneous group of mechanically ventilated patients, probably due to confounding eff ects of comorbidities, among other factors. en_US
dc.format.extent 2 pag. en
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher BioMed Central en_US
dc.relation.ispartof Critical Care en_US
dc.rights © 2011 BioMed Central Ltd en_US
dc.subject.other cf-DNA en_US
dc.subject.other Mechanical ventilation en_US
dc.title Diagnostic potential of circulating cell-free DNA in patients needing mechanical ventilation: Promises and challenges en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://ccforum.com/content/15/5/187 es_ES
dc.identifier.doi 10.1186/cc10365 es_ES
dc.identifier.publicationfirstpage 187 es_ES
dc.identifier.publicationlastpage 187 es_ES
dc.identifier.publicationvolume 15 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM Montiel López, Carmen (259197)

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