Nutrition and physical activity programs for obesity treatment (PRONAF study): Methodological approach of the project
Author
Zapico, Augusto G.; Benito, Pedro José; González-Gross, Marcela Marcela; Peinado, Ana Belén; Morencos, Esther; Romero Moraleda, Blanca
Entity
UAM. Departamento de MedicinaPublisher
BioMed CentralDate
2012-12-26Citation
10.1186/1471-2458-12-1100
BMC Public Health 12.1 (2012): 1100
ISSN
1471-2458DOI
10.1186/1471-2458-12-1100Funded by
The PRONAF Study takes place with the financial support of the Ministerio de Ciencia e Innovación, Convocatoria de Ayudas I + D 2008, Proyectos de Investigación Fundamental No Orientada, del VI Plan de Investigación Nacional 2008–2011, (Contract DEP2008-06354-C04-01). Morencos E, Romero B, RojoTirado MA and Cupeiro R had financial support from Technical University of Madrid. Additional support from Ministerio de Ciencia e Innovación, (Contract DEP2011-13140-E) was obtainedEditor's Version
http://dx.doi.org/:10.1186/1471-2458-12-1100Subjects
Caloric restriction; Exercise; Obesity; Overweight; Weight loss; MedicinaRights
© 2012 Zapico et al.; licensee BioMed CentralAbstract
Background: At present, scientific consensus exists on the multifactorial etiopatogenia of obesity. Both
professionals and researchers agree that treatment must also have a multifactorial approach, including diet, physical
activity, pharmacology and/or surgical treatment. These two last ones should be reserved for those cases of morbid
obesities or in case of failure of the previous ones. The aim of the PRONAF study is to determine what type of
exercise combined with caloric restriction is the most appropriate to be included in overweigth and obesity
intervention programs, and the aim of this paper is to describe the design and the evaluation methods used to
carry out the PRONAF study.
Methods/design: One-hundred nineteen overweight (46 males) and 120 obese (61 males) subjects aged
18–50 years were randomly assigned to a strength training group, an endurance training group, a combined
strength + endurance training group or a diet and physical activity recommendations group. The intervention
period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation). All
subjects followed a hypocaloric diet (25-30% less energy intake than the daily energy expenditure estimated by
accelerometry). 29–34% of the total energy intake came from fat, 14–20% from protein, and 50–55% from
carbohydrates. The mayor outcome variables assesed were, biochemical and inflamatory markers, body
composition, energy balance, physical fitness, nutritional habits, genetic profile and quality of life. 180 (75.3%)
subjects finished the study, with a dropout rate of 24.7%. Dropout reasons included: personal reasons 17 (28.8%),
low adherence to exercise 3 (5.1%), low adherence to diet 6 (10.2%), job change 6 (10.2%), and lost interest
27 (45.8%).
Discussion: Feasibility of the study has been proven, with a low dropout rate which corresponds to the estimated
sample size. Transfer of knowledge is foreseen as a spin-off, in order that overweight and obese subjects can
benefit from the results. The aim is to transfer it to sports centres. Effectiveness on individual health-related
parameter in order to determine the most effective training programme will be analysed in forthcoming
publications.
Files in this item

Google Scholar:Zapico, Augusto G.
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Benito, Pedro José
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González-Gross, Marcela Marcela
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Peinado, Ana Belén
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Morencos, Esther
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Romero Moraleda, Blanca
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Rojo-Tirado, Miguel A.
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Cupeiro, Rocío
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Szendrei, Barbara
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Butragueño, Javier
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Bermejo, Maite
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Alvarez-Sánchez, María
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García-Fuentes, Miguel A.
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Gómez-Candela, Carmen
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Bermejo, Laura María
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Fernández Fernández, Ceila
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Calderón, Francisco Javier
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