Are the mesothelial-to-mesenchymal transition, sclerotic peritonitis syndromes, and encapsulating peritoneal sclerosis part of the same process?
Entity
UAM. Departamento de MedicinaPublisher
Hindawi Publishing CorporationDate
2013-03-15Citation
10.1155/2013/263285
International Journal of Nephrology 2013 (2013): 263285
ISSN
2090-214X (print); 2090-2158 (online)DOI
10.1155/2013/263285Funded by
This work was supported by Grant SAF2010-21249 from the Ministerio de Economía y Competitividad to M. López- Cabrera and by Grant S2010/BMD-2321 from Comunidad Autónoma de Madrid to M. López-Cabrera and R. Selgas This work was also partially supported by Grants PI 09/0776 from Fondo de Investigaciones Sanitarias to A. A. Peralta and RETICS 06/0016 (REDinREN, Fondos FEDER, EU) to R. SelgasProject
Comunidad de Madrid. S2010/BMD-2321/FIBROTEAMSubjects
Peritoneal dialysis; MedicinaRights
Copyright © 2013 Jesus Loureiro et al.Abstract
Mesothelial-to-mesenchymal transition (MMT) is an autoregulated physiological process of tissue repair that in uncontrolled conditions,
such as peritoneal dialysis (PD), can lead to peritoneal fibrosis. The maximumexpression of sclerotic peritoneal syndromes
(SPS) is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. The SPS includes a wide range of
peritoneal fibrosis that appears progressively and is considered as a reversible process, while EPS does not. EPS is a serious
complication of PD characterized by a progressive intra-abdominal inflammatory process that results in bridles and severe fibrous
tissue formation which cover and constrict the viscera. Recent studies show that transdifferentiated mesothelial cells isolated from
the PD effluent correlate very well with the clinical events such as the number of hemoperitoneum and peritonitis, as well as with
PD function (lower ultrafiltration and high Cr-MTC). In addition, in peritoneal biopsies from PD patients, the MMT correlates
very well with anatomical changes (fibrosis and angiogenesis). However, the pathway to reach EPS from SPS has not been fully and
completely established. Herein, we present important evidence pointing to the MMT that is present in the initial peritoneal fibrosis
stages and it is perpetual over time, with at least theoretical possibility that MMT initiated the fibrosing process to reach EPS
Files in this item
Google Scholar:Loureiro, Jesús
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González-Mateo, Guadalupe Tirma
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Jiménez Heffernan, José Antonio
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Selgas Gutiérrez, Rafael
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López-Cabrera, Manuel
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Aguilera Peralta, Abelardo
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