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Are the mesothelial-to-mesenchymal transition, sclerotic peritonitis syndromes, and encapsulating peritoneal sclerosis part of the same process?

Author
Loureiro, Jesús; González-Mateo, Guadalupe Tirma; Jiménez Heffernan, José Antoniountranslated; Selgas Gutiérrez, Rafael; López-Cabrera, Manuel; Aguilera Peralta, Abelardo
Entity
UAM. Departamento de Medicina
Publisher
Hindawi Publishing Corporation
Date
2013-03-15
Citation
10.1155/2013/263285
International Journal of Nephrology 2013 (2013): 263285
 
 
 
ISSN
2090-214X (print); 2090-2158 (online)
DOI
10.1155/2013/263285
Funded by
This work was supported by Grant SAF2010-21249 from the Ministerio de Economía y Competitividad to M. López- Cabrera and by Grant S2010/BMD-2321 from Comunidad Autónoma de Madrid to M. López-Cabrera and R. Selgas This work was also partially supported by Grants PI 09/0776 from Fondo de Investigaciones Sanitarias to A. A. Peralta and RETICS 06/0016 (REDinREN, Fondos FEDER, EU) to R. Selgas
Project
Comunidad de Madrid. S2010/BMD-2321/FIBROTEAM
Subjects
Peritoneal dialysis; Medicina
URI
http://hdl.handle.net/10486/663543
Rights
Copyright © 2013 Jesus Loureiro et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Mesothelial-to-mesenchymal transition (MMT) is an autoregulated physiological process of tissue repair that in uncontrolled conditions, such as peritoneal dialysis (PD), can lead to peritoneal fibrosis. The maximumexpression of sclerotic peritoneal syndromes (SPS) is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. The SPS includes a wide range of peritoneal fibrosis that appears progressively and is considered as a reversible process, while EPS does not. EPS is a serious complication of PD characterized by a progressive intra-abdominal inflammatory process that results in bridles and severe fibrous tissue formation which cover and constrict the viscera. Recent studies show that transdifferentiated mesothelial cells isolated from the PD effluent correlate very well with the clinical events such as the number of hemoperitoneum and peritonitis, as well as with PD function (lower ultrafiltration and high Cr-MTC). In addition, in peritoneal biopsies from PD patients, the MMT correlates very well with anatomical changes (fibrosis and angiogenesis). However, the pathway to reach EPS from SPS has not been fully and completely established. Herein, we present important evidence pointing to the MMT that is present in the initial peritoneal fibrosis stages and it is perpetual over time, with at least theoretical possibility that MMT initiated the fibrosing process to reach EPS
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Google™ Scholar:Loureiro, Jesús - González-Mateo, Guadalupe Tirma - Jiménez Heffernan, José Antonio - Selgas Gutiérrez, Rafael - López-Cabrera, Manuel - Aguilera Peralta, Abelardo

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