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Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke

Author
Gutiérrez-Fernández, María; Fuentes Gimeno, Blanca; Rodríguez-Frutos, Berta; Ramos-Cejudo, Jaime; Vallejo-Cremades, María Teresa; Díez-Tejedor, Exuperio
Entity
UAM. Departamento de Medicina
Publisher
Foundation for Cellular and Molecular Medicine; John Wiley & Sons Ltd
Date
2012-10-01
Citation
10.1111/j.1582-4934.2012.01575.x
Journal of Cellular and Molecular Medicine 16.10 (2012): 2280-2290
 
 
 
ISSN
1582-1838 (print); 1582-4934 (online)
DOI
10.1111/j.1582-4934.2012.01575.x
Funded by
Supported by research grants from PI060575 and PS09/01606 (Spanish Ministry of Science), CIDEM, RENEVAS (RD07/0026/2003) (Spanish Neurovascular Network) and FEDER. Research Institute Carlos III, Ministry Science and Innovation. Also, we have obtained research grants from Ferrer Group, EVER Neuro Pharma and Cellerix
Subjects
Brain plasticity; Brain protection; Brain repair; Stem cell therapy; Trophic factors; Medicina
URI
http://hdl.handle.net/10486/663635
Rights
© 2012 The Authors; © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

Abstract

Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic factor- and stem cell-based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis, all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental animal models to recent and ongoing clinical trials are reviewed here
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Google™ Scholar:Gutiérrez-Fernández, María - Fuentes Gimeno, Blanca - Rodríguez-Frutos, Berta - Ramos-Cejudo, Jaime - Vallejo-Cremades, María Teresa - Díez-Tejedor, Exuperio

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  • Producción científica en acceso abierto de la UAM [15094]

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Universidad Autónoma de Madrid. Biblioteca
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