Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke
Entity
UAM. Departamento de MedicinaPublisher
Foundation for Cellular and Molecular Medicine; John Wiley & Sons LtdDate
2012-10-01Citation
10.1111/j.1582-4934.2012.01575.x
Journal of Cellular and Molecular Medicine 16.10 (2012): 2280-2290
ISSN
1582-1838 (print); 1582-4934 (online)DOI
10.1111/j.1582-4934.2012.01575.xFunded by
Supported by research grants from PI060575 and PS09/01606 (Spanish Ministry of Science), CIDEM, RENEVAS (RD07/0026/2003) (Spanish Neurovascular Network) and FEDER. Research Institute Carlos III, Ministry Science and Innovation. Also, we have obtained research grants from Ferrer Group, EVER Neuro Pharma and CellerixSubjects
Brain plasticity; Brain protection; Brain repair; Stem cell therapy; Trophic factors; MedicinaRights
© 2012 The Authors; © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing LtdAbstract
Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies
that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such
as trophic factor- and stem cell-based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis,
all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However,
even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have
not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors,
drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental
animal models to recent and ongoing clinical trials are reviewed here
Files in this item
Google Scholar:Gutiérrez-Fernández, María
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Fuentes Gimeno, Blanca Eulalia
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Rodríguez-Frutos, Berta
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Ramos-Cejudo, Jaime
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Vallejo-Cremades, María Teresa
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Díez Tejedor, Exuperio
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