Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke

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dc.contributor.author Gutiérrez-Fernández, María
dc.contributor.author Fuentes Gimeno, Blanca
dc.contributor.author Rodríguez-Frutos, Berta
dc.contributor.author Ramos-Cejudo, Jaime
dc.contributor.author Vallejo-Cremades, María Teresa
dc.contributor.author Díez-Tejedor, Exuperio
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.date.accessioned 2015-02-06T11:38:05Z
dc.date.available 2015-02-06T11:38:05Z
dc.date.issued 2012-10-01
dc.identifier.citation Journal of Cellular and Molecular Medicine 16.10 (2012): 2280-2290 en_US
dc.identifier.issn 1582-1838 (print) en_US
dc.identifier.issn 1582-4934 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/663635
dc.description.abstract Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic factor- and stem cell-based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis, all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental animal models to recent and ongoing clinical trials are reviewed here en_US
dc.description.sponsorship Supported by research grants from PI060575 and PS09/01606 (Spanish Ministry of Science), CIDEM, RENEVAS (RD07/0026/2003) (Spanish Neurovascular Network) and FEDER. Research Institute Carlos III, Ministry Science and Innovation. Also, we have obtained research grants from Ferrer Group, EVER Neuro Pharma and Cellerix en_US
dc.format.extent 11 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Foundation for Cellular and Molecular Medicine en_US
dc.publisher John Wiley & Sons Ltd en_US
dc.relation.ispartof Journal of Cellular and Molecular Medicine en_US
dc.rights © 2012 The Authors en_US
dc.rights © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd en_US
dc.subject.other Brain plasticity en_US
dc.subject.other Brain protection en_US
dc.subject.other Brain repair en_US
dc.subject.other Stem cell therapy en_US
dc.subject.other Trophic factors en_US
dc.title Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.identifier.doi 10.1111/j.1582-4934.2012.01575.x es_ES
dc.identifier.publicationfirstpage 2280 es_ES
dc.identifier.publicationissue 10 es_ES
dc.identifier.publicationlastpage 2290 es_ES
dc.identifier.publicationvolume 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM Díez Tejedor, Exuperio (258291)


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