The genome sequence of the emerging common midwife toad virus identifies an evolutionary intermediate within ranaviruses
Entity
UAM. Departamento de Biología MolecularPublisher
American Society for MicrobiologyDate
2012-04-01Citation
10.1128/JVI.07108-11
Journal of Virology 86.7 (2012): 3617-3625
ISSN
0022-538X (print); 1098-5514 (online)DOI
10.1128/JVI.07108-11Funded by
This work was supported by grant AGL 2009-08711 from the Spanish Ministerio de Ciencia e Innovación. Alberto López-Bueno and Carla Mavián are recipients of the Ramón y Cajal and Formación del Personal Investigador fellowships, respectively, from the same institutionEditor's Version
http://dx.doi.org/10.1128/JVI.07108-11Subjects
Genome; Virus; Ranaviruses; Biología y Biomedicina / BiologíaRights
© 2014, American Society for MicrobiologyAbstract
Worldwide amphibian population declines have been ascribed to global warming, increasing pollution levels, and other factors
directly related to human activities. These factors may additionally be favoring the emergence of novel pathogens. In this report,
we have determined the complete genome sequence of the emerging common midwife toad ranavirus (CMTV), which has caused
fatal disease in several amphibian species across Europe. Phylogenetic and gene content analyses of the first complete genomic
sequence from a ranavirus isolated in Europe show that CMTV is an amphibian-like ranavirus (ALRV). However, the CMTV
genome structure is novel and represents an intermediate evolutionary stage between the two previously described ALRV
groups. We find that CMTV clusters with several other ranaviruses isolated from different hosts and locations which might also
be included in this novel ranavirus group. This work sheds light on the phylogenetic relationships within this complex group of
emerging, disease-causing viruses.
Files in this item
Google Scholar:Mavian, Carla Nartuhi
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López Bueno, Alberto
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Balseiro, Ana
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Casáis, Rosa
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Alcamí, Antonio
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Alejo, Alí
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