Cell stress proteins in atherothrombosis
Entity
UAM. Departamento de MedicinaPublisher
Hindawi Publishing CorporationDate
2012-08-17Citation
10.1155/2012/232464
Oxidative Medicine and Cellular Longevity 2012 (2012): 232464
ISSN
1942-0900 (print); 1942-0994 (online)DOI
10.1155/2012/232464Funded by
This work was supported by the Spanish Ministerio de Ciencia y Tecnología (SAF 2010-21852), Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Redes RECAVA (RD06/0014/0035),Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (PI10/00072), and Sociedad Española de Arterosclerosis and Fundación LillySubjects
antioxidant activity; apoptosis; blood vessel wall; cellular immunity; protein expression; thrombosis; MedicinaRights
© 2012 Julio Madrigal-Matute et al.Abstract
Cell stress proteins (CSPs) are a large and heterogenous family of proteins, sharing two main characteristics: their levels and/or location are modified under stress and most of them can exert a chaperon function inside the cells. Nonetheless, they are also involved in the modulation of several mechanisms, both at the intracellular and the extracellular compartments. There are more than 100 proteins belonging to the CSPs family, among them the thioredoxin (TRX) system, which is the focus of the present paper. TRX system is composed of several proteins such as TRX and peroxiredoxin (PRDX), two thiol-containing enzymes that are key players in redox homeostasis due to their ability to scavenge potential harmful reactive oxygen species. In addition to their main role as antioxidants, recent data highlights their function in several processes such as cell signalling, immune inflammatory responses, or apoptosis, all of them key mechanisms involved in atherothrombosis. Moreover, since TRX and PRDX are present in the pathological vascular wall and can be secreted under prooxidative conditions to the circulation, several studies have addressed their role as diagnostic, prognostic, and therapeutic biomarkers of cardiovascular diseases (CVDs)
Files in this item
Google Scholar:Madrigal-Matute, Julio
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Martínez-Pinna, Roxana
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Fernandez-Garcia, Carlos Ernesto
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Ramos-Mozo, Priscila
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Burillo, Elena
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Egido de los Ríos, Jesús
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Blanco-Colio, Luís Miguel
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Martín Ventura, José Luis
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