dc.contributor.author | Matesanz García, Ana Isabel | |
dc.contributor.author | Joie, Céline | |
dc.contributor.author | Souza, Pilar | |
dc.contributor.other | UAM. Departamento de Química Inorgánica | es_ES |
dc.date.accessioned | 2015-04-15T08:45:41Z | |
dc.date.available | 2015-04-15T08:45:41Z | |
dc.date.issued | 2010-08-14 | |
dc.identifier.citation | Dalton Transactions 39.30 (2010): 7059-7065 | en_US |
dc.identifier.issn | 1477-9226 (print) | es_ES |
dc.identifier.issn | 1477-9234 (on line) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/665092 | |
dc.description | Dalton Transactions 39.30 (2010): 7059-7065. Reproduced by permission of The Royal Society of Chemistry | en_US |
dc.description.abstract | The preparation and characterization of 3,5-diacetyl-1,2,4-triazol bis(4,4-dimethylthiosemicarbazone) ligand, H3L1, and its dinuclear platinum complex [Pt(μ-HL1)]2 is described. The crystal and molecular structure of the platinum complex has been resolved by single crystal X-ray diffraction. The ligands coordinate, in an asymmetric dideprotonate form, to the platinum ions in a tridentate fashion (NNS) and S-bridging bonding modes. Thus the molecular units of the platinum complexes are stacked as dimers. The new compounds synthesized together with the analogous monosubstituted ligand 3,5-diacetyl-1,2,4-triazol bis(4-methylthiosemicarbazone) (H5L2) and its dinuclear platinum(ii) complex [Pt(μ-H3L2)]2 have been evaluated for antiproliferative activity in vitro against NCI-H460, A2780 and A2780cisR human cancer cell lines. The cytotoxicity data suggest that these compounds may be endowed with important antitumor properties, especially H3L 1 and [Pt(μ-H3L2)]2 since they not only circumvent cisplatin resistance in A2780cisR cells but also exhibit high antiproliferative activity in human non-small cell lung cancer NCI-H460 cells. Subsequent nephrotoxic study, in LLC-PK1 cells, show that the four compounds investigated exhibit very low nephrotoxicity with respect to cisplatin | en_US |
dc.description.sponsorship | We are grateful toMinisterio de Ciencia e Innovación, Instituto de Salud Carlos III (PI080525), Universidad Autónoma de Madrid and Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain for financial support. C. J. also thanks Erasmus Programme for its Research Placement at Universidad Autónoma de Madrid | en_US |
dc.format.extent | 7 pag. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.ispartof | Dalton Transactions | en_US |
dc.rights | © The Royal Society of Chemistry 2010 | en_US |
dc.subject.other | Chemistry | en_US |
dc.title | Chemistry, antiproliferative activity and low nephrotoxicity of 3,5-diacetyl-1,2,4-triazol bis(4N-thiosemicarbazone) ligands and their platinum(ii) complexes | en_US |
dc.type | article | en |
dc.subject.eciencia | Química | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/c003007d | en_US |
dc.identifier.doi | 10.1039/c003007d | es_ES |
dc.identifier.publicationfirstpage | 7059 | es_ES |
dc.identifier.publicationissue | 30 | es_ES |
dc.identifier.publicationlastpage | 7065 | es_ES |
dc.identifier.publicationvolume | 39 | es_ES |
dc.type.version | info:eu-repo/semantics/acceptedVersion | en |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Ciencias | |