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dc.contributor.authorMatesanz, Ana I.
dc.contributor.authorHernández, Carolina
dc.contributor.authorRodríguez, Ana María
dc.contributor.authorSouza, Pilar
dc.contributor.otherUAM. Departamento de Química Inorgánicaes_ES
dc.date.accessioned2015-04-20T10:04:21Z
dc.date.available2015-04-20T10:04:21Z
dc.date.issued2011-12-01
dc.identifier.citationJournal of Inorganic Biochemistry 105.12 (2011): 1613-1622en_US
dc.identifier.issn0162-0134 (print)es_ES
dc.identifier.issn1873-3344 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/665272
dc.descriptionthis is the author’s version of a work that was accepted for publication in Journal of Inorganic Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Inorganic Biochemistry 105.12 (2011): 1613-1622 DOI http://dx.doi.org/10.1016/j.jinorgbio.2011.08.014en_US
dc.description.abstractTreatment of 4N-monosubstituted bis(thiosemicarbazone) ligands of 3,5-diacetyl-1,2,4-triazol series with lithium tetrachloridopalladate gave the dinuclear complexes of general formula [Pd(μ-H 3L 1-5)] 2, but using dichloridobistriphenylphosphinepalladium(II) salt, the first mononuclear bis(thiosemicarbazone)-palladium-triphenylphosphine complexes of the 3,5-diacetyl-1,2,4-triazol series, [Pd(H 3L 1-5)PPh 3], have been obtained. All the compounds have been characterized by elemental analysis and by IR and NMR spectroscopy, and the crystal and molecular structures of dinuclear complexes [Pd(μ-H 3L 3)] 2 and [Pd(μ-H 3L 5)] 2 as well as mononuclear complexes [Pd(H 3L 1)PPh 3], [Pd(H 3L 2)PPh 3], [Pd(H 3L 3)PPh 3] and [Pd(H 3L 4)PPh 3] have been determined by X-ray crystallography. The new compounds synthesized have been evaluated for antiproliferative activity in vitro against NCI-H460, A2780 and A2780cisR human cancer cell lines. Subsequent toxicity study, on normal renal LLC-PK1 cells, shows that all compounds investigated exhibit very low toxicity on kidney cells with respect to cisplatinen_US
dc.description.sponsorshipWe are grateful to Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI080525), Universidad Autónoma de Madrid and Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain for financial supporten_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevier Inc.en_US
dc.relation.ispartofJournal of Inorganic Biochemistryen_US
dc.rights© 2011 Elsevier Inc. All rights reserveden_US
dc.subject.other1,2,4-Triazolen_US
dc.subject.otherAntitumour agentsen_US
dc.subject.otherPalladium complexesen_US
dc.subject.otherRenal toxicityen_US
dc.subject.otherThiosemicarbazoneen_US
dc.subject.otherX-ray diffractionen_US
dc.title3,5-Diacetyl-1,2,4-triazol bis( 4N-substituted thiosemicarbazone) palladium(II) complexes: Synthesis, structure, antiproliferative activity and low toxicity on normal kidney cellsen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jinorgbio.2011.08.014es_ES
dc.identifier.doi10.1016/j.jinorgbio.2011.08.014es_ES
dc.identifier.publicationfirstpage1613es_ES
dc.identifier.publicationissue12es_ES
dc.identifier.publicationlastpage1622es_ES
dc.identifier.publicationvolume105es_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.ccReconocimiento – NoComercial – SinObraDerivadaes_ES
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Ciencias


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