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α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach
Metadatos
Title:α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach
Author:Matesanz, Ana I.; Souza, Pilar
Entity:UAM. Departamento de Química Inorgánica
Publisher:Bentham Science Publishers
Date:2009-12-01
Citation:
10.2174/138955709789957422
Mini-Reviews in Medicinal Chemistry 9.12 (2009): 1389-1396
ISSN:1389-5575 (print); 1875-5607 (online)
DOI:10.2174/138955709789957422
Funded by:The authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain
α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships