α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach

Matesanz, Ana I.; Souza, Pilar

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α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach

Metadatos

Title: α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach

Author: Matesanz, Ana I.; Souza, Pilar

Entity: UAM. Departamento de Química Inorgánica

Publisher: Bentham Science Publishers

Date: 2009-12-01

Citation: Mini-Reviews in Medicinal Chemistry 9.12 (2009): 1389-1396

ISSN: 1389-5575 (print); 1875-5607 (online)

DOI: 10.2174/138955709789957422

Funded by: The authors research work presented in this review was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (PI040354 and PI080525), Comunidad de Madrid (GR/SAL/0180/2004) and Universidad Autónoma de Madrid-Comunidad de Madrid (CCG08-UAM/SAL-4000) of Spain

Editor's Version: http://dx.doi.org/10.2174/138955709789957422

Subjects: α-N-heterocyclic thiosemicarbazone; Antitumour agents; Bis(thiosemicarbazone); Metal complexes; Ribonucleotide reductase inhibitors; Structure-activity relationships; Química

URI: http://hdl.handle.net/10486/665374

Abstract:

α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships

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