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dc.contributor.authorGonzalo, Soledad
dc.contributor.authorPulido-Reyes, Gerardo
dc.contributor.authorFernández-Piñas, Francisca
dc.contributor.authorBonzongo, Jean Claude
dc.contributor.authorLeganés, Francisco
dc.contributor.authorRosal, Roberto
dc.contributor.authorGarcía-Calvo, Eloy
dc.contributor.authorRodea-Palomares, Ismael
dc.contributor.otherUAM. Departamento de Biologíaes_ES
dc.date.accessioned2015-05-06T08:56:49Z
dc.date.available2015-05-06T08:56:49Z
dc.date.issued2014-10-23
dc.identifier.citationPlos One 9.10 (2014): e109645en_US
dc.identifier.issn1932-6203 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/665942
dc.description.abstractAggregation raises attention in Nanotoxicology due to its methodological implications. Aggregation is a physical symptom of a more general physicochemical condition of colloidal particles, namely, colloidal stability. Colloidal stability is a global indicator of the tendency of a system to reduce its net surface energy, which may be achieved by homo-aggregation or hetero-aggregation, including location at bio-interfaces. However, the role of colloidal stability as a driver of ENM bioactivity has received little consideration thus far. In the present work, which focuses on the toxicity of nanoscaled Fe° nanoparticles (nZVI) towards a model microalga, we demonstrate that colloidal stability is a fundamental driver of ENM bioactivity, comprehensively accounting for otherwise inexplicable differential biological effects. The present work throws light on basic aspects of Nanotoxicology, and reveals a key factor which may reconcile contradictory results on the influence of aggregation in bioactivity of ENMsen_US
dc.description.sponsorshipThis research was supported by the Comunidad de Madrid grants S-0505/AMB/0321 and S-2009/AMB/1511 (Microambiente-CM). The Spanish Ministry of Science and Innovation grants CGL2010-15675 sub-program BOS, and the CTM2008-04239/TECNO, and the Spanish Ministry of Economy and Competitiveness (MINECO) grants CTM2013-45775-C2-1-R, CTM2013-45775-C2-2-R and the US-National Science Foundation, grant number CBET-0853347en_US
dc.format.extent12 pag.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.rightsThis is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purposeen_US
dc.subjectbiological activityen_US
dc.subjectcolloiden_US
dc.subjectcolloidal stabilityen_US
dc.subjectin vitro studyen_US
dc.subjectmicroalgaen_US
dc.subjectmolecular stabilityen_US
dc.subjectnanotoxicologyen_US
dc.subjectphysical chemistryen_US
dc.titleA colloidal singularity reveals the crucial role of colloidal stability for nanomaterials in-vitro toxicity testing: nZVI-microalgae colloidal system as a case studyen_US
dc.typearticleen
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.identifier.doi10.1371/journal.pone.0109645es_ES
dc.identifier.publicationfirstpagee109645es_ES
dc.identifier.publicationissue10es_ES
dc.identifier.publicationlastpagee109645es_ES
dc.identifier.publicationvolume9es_ES
dc.relation.projectIDComunidad de Madrid. S2009/AMB-1511/MICROAMBIENTEes_ES
dc.relation.projectIDComunidad de Madrid. S0505/AMB-0321/MICROAMBIENTEes_ES
dc.rights.ccEsta obra está bajo una licencia Creative Commons de Dominio Público CC0 1.0 Universales_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMFernández Piñas, Francisca (260189)
dc.authorUAMLeganés Nieto, Francisco (261828)
dc.authorUAMRodea Palomares, Ismael Martín (263998)
dc.facultadUAMFacultad de Ciencias


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