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Leptin in early life: A key factor for the development of the adult metabolic profile

Author
Granado, Miriam; Fuente-Martín, Esther; García-Cáceres, Cristina; Argente, Jesús; Chowen, Julie Ann
Entity
UAM. Departamento de Fisiología; UAM. Departamento de Pediatría
Publisher
Karger
Date
2012-03-01
Citation
10.1159/000336967
Obesity Facts 5.1 (2012): 138-150
 
 
 
ISSN
1662-4025 (print); 1662-4033 (online)
DOI
10.1159/000336967
Subjects
Adipose tissue; Hypothalamus; Leptin; Metabolic programming; Medicina
URI
http://hdl.handle.net/10486/666072
Rights
© 2012 S. Karger GmbH, Freiburg

Abstract

Leptin levels during the perinatal period are important for the development of metabolic systems involved in energy homeostasis. In rodents, there is a postnatal leptin surge, with circulating leptin levels increasing around postnatal day (PND) 5 and peaking between PND 9 and PND 10. At this time circulating leptin acts as an important trophic factor for the development of hypothalamic circuits that control energy homeostasis and food seeking and reward behaviors. Blunting the postnatal leptin surge results in long-term leptin insensitivity and increased susceptibility to diet-induced obesity during adulthood. Pharmacologically increased leptin levels in the postnatal period also have long-term effects on metabolism. Nevertheless, this effect is controversial as postnatal hyperleptinemia is reported to both increase and decrease the predisposition to obesity in adulthood. The different effects reported in the literature could be explained by the different moments at which this hormone was administered, suggesting that modifications of the neonatal leptin surge at specific time points could selectively affect the development of central and peripheral systems that are undergoing modifications at this moment resulting in different metabolic and behavioral outcomes. In addition, maternal nutrition and the hormonal environment during pregnancy and lactation may also modulate the offspring’s response to postnatal modifications in leptin levels. This review highlights the importance of leptin levels during the perinatal period in the development of metabolic systems that control energy homeostasis and how modifications of these levels may induce long-lasting and potentially irreversible effects on metabolism
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Google™ Scholar:Granado, Miriam - Fuente-Martín, Esther - García-Cáceres, Cristina - Argente, Jesús - Chowen, Julie Ann

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  • Producción científica en acceso abierto de la UAM [14705]

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Universidad Autónoma de Madrid. Biblioteca
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