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Translocated LPS might cause endotoxin tolerance in circulating monocytes of cystic fibrosis patients

Author
Del Campo, Rosa; Martínez, Eriel; Del Fresno, Carlos; Alenda, Raquel; Gómez-Piña, Vanesa; Fernández-Ruíz, Irene; Siliceo, María; Jurado, Teresa; Toledano, Víctor; Arnalich Fernández, Franciscountranslated; García Rio, Franciscountranslated; López-Collazo, Eduardo
Entity
UAM. Departamento de Medicina
Publisher
Public Library of Science
Date
2011-12-28
Citation
10.1371/journal.pone.0029577
Plos One 6.12 (2011): e29577
 
 
 
ISSN
1932-6203 (online)
DOI
10.1371/journal.pone.0029577
Funded by
This work was supported by a ‘‘Ministerio de Ciencia e Innovación’’ grant to EL-C. RdC has a contract from the Instituto de Salud Carlos III-FIS (CB05/ 137)
Subjects
Biological Transport; Cystic Fibrosis; Electrophoresis, Polyacrylamide Gel; Endotoxins; Monocytes; Medicina
URI
http://hdl.handle.net/10486/666139
Rights
© 2011 del Campo et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Cystic Fibrosis (CF) is an inherited pleiotropic disease that results from abnormalities in the gene codes of a chloride channel. The lungs of CF patients are chronically infected by several pathogens but bacteraemia have rarely been reported in this pathology. Besides that, circulating monocytes in CF patients exhibit a patent Endotoxin Tolerance (ET) state since they show a significant reduction of the inflammatory response to bacterial stimulus. Despite a previous description of this phenomenon, the direct cause of ET in CF patients remains unknown. In this study we have researched the possible role of microbial/endotoxin translocation from a localized infection to the bloodstream as a potential cause of ET induction in CF patients. Plasma analysis of fourteen CF patients revealed high levels of LPS compared to healthy volunteers and patients who suffer from Chronic Obstructive Pulmonary Disease. Experiments in vitro showed that endotoxin concentrations found in plasma of CF patients were enough to induce an ET phenotype in monocytes from healthy controls. In agreement with clinical data, we failed to detect bacterial DNA in CF plasma. Our results suggest that soluble endotoxin present in bloodstream of CF patients causes endotoxin tolerance in their circulating monocytes
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Google™ Scholar:Del Campo, Rosa - Martínez, Eriel - Del Fresno, Carlos - Alenda, Raquel - Gómez-Piña, Vanesa - Fernández-Ruíz, Irene - Siliceo, María - Jurado, Teresa - Toledano, Víctor - Arnalich Fernández, Francisco - García Rio, Francisco - López-Collazo, Eduardo

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  • Producción científica en acceso abierto de la UAM [16630]

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All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
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