UAM_Biblioteca | Unified search engine | Scientific Production Portal | UAM Research Data Repository
Universidad Autónoma de Madrid
Biblos-e Archivo
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
    • español
    • English
  • English 
    • español
    • English
  • Log in
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search Biblos-e Archivo

Advanced Search

Browse

All of Biblos-e ArchivoCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultiesThis CollectionBy Issue DateAuthorsTitlesSubjectsFaculties

My Account

Log inRegister

Statistics

View Usage Statistics

Help

Information about Biblos-e ArchivoI want to submit my workI want to submit my doctoral thesisFrequently Asked QuestionsCopyrightsFinancial Agencies and OA policy

UAM_Biblioteca

View Item 
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item

Fcγ receptor deficiency attenuates diabetic nephropathy

Author
López-Parra, Virginia; Mallavia, Beñat; López-Franco, Óscar; Ortiz-Muñoz, Guadalupe; Oguiza, Ainhoa; Recio, Carlota; Blanco, Julia A Parra; Nimmerjahn, F.; Egido de los Ríos, Jesús; Gómez-Guerrero, Carmen
Entity
UAM. Departamento de Medicina
Publisher
American Society of Nephrology
Date
2012-09-01
Citation
10.1681/ASN.2011080822
Journal of the American Society of Nephrology 23.9 (2012): 1518–1527
 
 
 
ISSN
1046-6673 (print); 2309-1518 (online)
DOI
10.1681/ASN.2011080822
Funded by
This study was supported by grants from Spanish Ministry of Science (SAF2009/11794), Ministry of Health (PI10/00072, RECAVA RD06/0014/0035), Lilly Foundation, FRIAT, and Spanish Society of Nephrology
Editor's Version
http://dx.doi.org/10.1681/ASN.2011080822
Subjects
Albuminuria; Diabetes Mellitus; Diabetic Nephropathies; Hypertrophy; Medicina
URI
http://hdl.handle.net/10486/666271
Rights
© 2012 by the American Society of Nephrology

Abstract

Among patients with diabetes, increased production of immunoglobulins against proteins modified by diabetes is associated with proteinuria and cardiovascular risk, suggesting that immune mechanisms may contribute to the development of diabetes complications, such as nephropathy. We investigated the contribution of IgG Fcg receptors to diabetic renal injury in hyperglycemic, hypercholesterolemic mice. Weused streptozotocin to induce diabetes in apolipoprotein E–deficientmice and in mice deficient in both apolipoprotein E and g-chain, the common subunit of activating Fcg receptors. After 15 weeks, the mice lacking Fcg receptors had significantly less albuminuria and renal hypertrophy, despite similar degrees of hyperglycemia and hypercholesterolemia, immunoglobulin production, and glomerular immune deposits. Moreover, diabetic Fcg receptor–deficient mice had less mesangial matrix expansion, inflammatory cell infiltration, and collagen and a-smooth muscle actin content in their kidneys. Accordingly, expression of genes involved in leukocyte infiltration, fibrosis, and oxidative stress was significantly reduced in diabetic kidneys and in mesangial cells cultured from Fcg receptor–deficient mice. In summary, preventing the activation of Fcg receptors alleviates renal hypertrophy, inflammation, and fibrosis in hypercholesterolemic mice with diabetes, suggesting that modulating Fcg receptor signaling may be renoprotective in diabetic nephropathy
Show full item record

Files in this item

Thumbnail
Name
receptor_lopez_JASN_2012.pdf
Size
1.547Mb
Format
PDF

Refworks Export

Delicious Save this on Delicious

Google™ Scholar:López-Parra, Virginia - Mallavia, Beñat - López-Franco, Óscar - Ortiz-Muñoz, Guadalupe - Oguiza, Ainhoa - Recio, Carlota - Blanco, Julia A Parra - Nimmerjahn, F. - Egido de los Ríos, Jesús - Gómez-Guerrero, Carmen

This item appears in the following Collection(s)

  • Producción científica en acceso abierto de la UAM [14764]

Related items

Showing items related by title, author, creator and subject.

  • Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice 

    Mallavia, Beñat; Oguiza, Ainhoa; López-Franco, Óscar; Recio, Carlota; Ortiz-Muñoz, Guadalupe; Lazaro, Iolanda; López-Parra, Virginia; Egido de los Ríos, Jesús; Gómez-Guerrero, Carmen
    2013-06-21
  • Targeting nf-κb by the cell-permeable nemo-binding domain peptide improves albuminuria and renal lesions in an experimental model of type 2 diabetic nephropathy 

    Opazo-Ríos, Lucas; Plaza, Anita; Matus, Yenniffer Sánchez; Bernal, Susana; Lopez-Sanz, Laura; Jimenez-Castilla, Luna; Carpio, Daniel; Droguett, Alejandra; Mezzano, Sergio; Egido, Jesús; Gomez-Guerrero, Carmen
    2020-06-13
  • Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice 

    Sastre, Cristina; Rubio-Navarro, Alfonso; Buendía, Irene; Gómez-Guerrero, Carmen; Blanco, Julia; Mas, Sebastián; Egido, Jesús; Blanco-Colio, Luis Miguel; Ortíz, Alberto; Moreno, Juan Antonio
    2013-12-30
All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
 

 

All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram