Show simple item record

dc.contributor.authorGironés Pujol, Nuria 
dc.contributor.authorCarbajosa, Sofía
dc.contributor.authorGuerrero, Néstor A.
dc.contributor.authorPoveda, Cristina
dc.contributor.authorChillón-Marinas, Carlos
dc.contributor.authorFresno Escudero, Manuel 
dc.contributor.otherUAM. Departamento de Biología Moleculares_ES
dc.date.accessioned2015-06-03T12:01:08Z
dc.date.available2015-06-03T12:01:08Z
dc.date.issued2014-01-01
dc.identifier.citationPLoS Neglected Tropical Diseases 8.11 (2014): e3337en_US
dc.identifier.issn1935-2727 (print)en_US
dc.identifier.issn1935-2735 (online)en_US
dc.identifier.urihttp://hdl.handle.net/10486/666580
dc.description.abstractChagas disease is caused by Trypanosoma cruzi infection, being cardiomyopathy the more frequent manifestation. New chemotherapeutic drugs are needed but there are no good biomarkers for monitoring treatment efficacy. There is growing evidence linking immune response and metabolism in inflammatory processes and specifically in Chagas disease. Thus, some metabolites are able to enhance and/or inhibit the immune response. Metabolite levels found in the host during an ongoing infection could provide valuable information on the pathogenesis and/or identify deregulated metabolic pathway that can be potential candidates for treatment and being potential specific biomarkers of the disease. To gain more insight into those aspects in Chagas disease, we performed an unprecedented metabolomic analysis in heart and plasma of mice infected with T. cruzi. Many metabolic pathways were profoundly affected by T. cruzi infection, such as glucose uptake, sorbitol pathway, fatty acid and phospholipid synthesis that were increased in heart tissue but decreased in plasma. Tricarboxylic acid cycle was decreased in heart tissue and plasma whereas reactive oxygen species production and uric acid formation were also deeply increased in infected hearts suggesting a stressful condition in the heart. While specific metabolites allantoin, kynurenine and p-cresol sulfate, resulting from nucleotide, tryptophan and phenylalanine/tyrosine metabolism, respectively, were increased in heart tissue and also in plasma. These results provide new valuable information on the pathogenesis of acute Chagas disease, unravel several new metabolic pathways susceptible of clinical management and identify metabolites useful as potential specific biomarkers for monitoring treatment and clinical severity in patientsen_US
dc.description.sponsorshipThis work was supported by ‘‘Ministerio de Ciencia e Innovación’’ (SAF2010-17833); ‘‘Fondo de Investigaciones Sanitarias’’ (PS09/00538 and PI12/00289); ‘‘Red de Investigación de Centros de Enfermedades Tropicales’’ (RICET RD12/0018/0004); European Union (HEALTH-FE-2008-22303, ChagasEpiNet); ‘‘Universidad Autónoma de Madrid’’ and ‘‘Comunidad de Madrid’’ (CC08-UAM/SAL-4440/08); AECID Cooperation with Argentine (A/025417/09 and A/031735/10), Comunidad de Madrid (S-2010/BMD-2332) and ‘‘Fundación Ramón Areces’’es_ES
dc.format.extent11 pag.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS Neglected Tropical Diseasesen_US
dc.rights© 2014 Gironès et al.es_ES
dc.subject.othermetabolomic profilingen_US
dc.subject.othermyocarditisen_US
dc.subject.otherglucose transporten_US
dc.subject.othertryptophan metabolismen_US
dc.subject.otherChagas diseaseen_US
dc.titleGlobal metabolomic profiling of acute myocarditis caused by Trypanosoma cruzi infectionen_US
dc.typearticleen
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.identifier.doi10.1371/journal.pntd.0003337es_ES
dc.identifier.publicationfirstpagee3337es_ES
dc.identifier.publicationissue11es_ES
dc.identifier.publicationlastpagee3337es_ES
dc.identifier.publicationvolume8es_ES
dc.relation.projectIDComunidad de Madrid. S2010/BMD-2332/INDISNETes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/223034en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_Es
dc.rights.accessRightsopenAccessen
dc.authorUAMGirones Pujol, Nuria (261139)
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMCentro de Biología Molecular Severo Ochoa (CBMSO)
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record