Post-translational modifications of exosomal proteins
Entity
UAM. Departamento de MedicinaPublisher
FrontiersDate
2014-08-11Citation
10.3389/fimmu.2014.00383
Frontiers in Immunology 5 (2014): 383
ISSN
1664-3224DOI
10.3389/fimmu.2014.00383Funded by
The authors thank Dr. S. Bartlett for assistance with English editing. This work was supported by SAF2011-25834 from the Spanish Ministry of Science and Innovation. INDISNET-S2011/BMD-2332 from the Comunidad de Madrid, Red Cardiovascular RD 12-0042-0056 from Instituto Salud Carlos III (ISCIII), ERC-2011-AdG 294340-GENTRIS, and COST-Action BN1202Project
Comunidad de Madrid. S2010/BMD-2332/INDISNET; info:eu-repo/grantAgreement/EC/FP7/294340Subjects
Post-translational modifications; Exosomes; Ubiquitination; Sorting; Multivesicular bodies; MedicinaRights
© 2014 Moreno-Gonzalo, Villarroya-Beltri and Sánchez-MadridAbstract
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies (MVBs) upon the fusion of these MVBs with the plasma membrane. The composition of exosomes is not random, suggesting that the incorporation of cargo into them is a regulated process. However, the mechanisms that control the sorting of protein cargo into exosomes are currently elusive. Here, we review the post-translational modifications detected in exosomal proteins, and discuss their possible role in their specific sorting into exosomes
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Google Scholar:Moreno Gonzalo, Olga
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Villarroya Beltri, Carolina
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Sánchez Madrid, Francisco
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