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Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish

Author
González-Rosa, Juan; Guzmán-Martínez, Gabriela; Marqués, Inés Joao; Sánchez-Iranzo, Héctor; Jiménez-Borreguero, Luis Jesús; Mercader, Nadia
Entity
UAM. Departamento de Medicina
Publisher
Public Library of Science
Date
2014-12-22
Citation
10.1371/journal.pone.0115604
Plos One 9.12 (2014): e115604
 
 
 
ISSN
1932-6203
DOI
10.1371/journal.pone.0115604
Funded by
Funding was from the Fundación CNIC Carlos III, the Fundación ProCNIC, the Spanish Ministry of Economy and Competitiveness (Tercel and BFU2011-25297 to N.M., FPU AP2008-00546 to J.M.G.-R. and FPU12/03007 to H.S-I.), the Community of Madrid (FIBROTEAM S2010/BMD- 2321 to N.M), PIEF-GA-2012-330728 to I.J.M. and an ERC Starting grant 337703 – zebraHeart to N.M.
Project
Comunidad de Madrid. S2010/BMD-2321/FIBROTEAM
Editor's Version
http://dx.doi.org/10.1371/journal.pone.0115604
Subjects
2D-echocardiography; Ventricular; Medicina
URI
http://hdl.handle.net/10486/667285
Note
The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files
Rights
© 2014 González-Rosa et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Aims: While zebrafish embryos are amenable to in vivo imaging, allowing the study of morphogenetic processes during development, intravital imaging of adults is hampered by their small size and loss of transparency. The use of adult zebrafish as a vertebrate model of cardiac disease and regeneration is increasing at high speed. It is therefore of great importance to establish appropriate and robust methods to measure cardiac function parameters. Methods and Results: Here we describe the use of 2D-echocardiography to study the fractional volume shortening and segmental wall motion of the ventricle. Our data show that 2D-echocardiography can be used to evaluate cardiac injury and also to study recovery of cardiac function. Interestingly, our results show that while global systolic function recovered following cardiac cryoinjury, ventricular wall motion was only partially restored. Conclusion: Cryoinjury leads to long-lasting impairment of cardiac contraction, partially mimicking the consequences of myocardial infarction in humans. Functional assessment of heart regeneration by echocardiography allows a deeper understanding of the mechanisms of cardiac regeneration and has the advantage of being easily transferable to other cardiovascular zebrafish disease models
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Google™ Scholar:González-Rosa, Juan - Guzmán-Martínez, Gabriela - Marqués, Inés Joao - Sánchez-Iranzo, Héctor - Jiménez-Borreguero, Luis Jesús - Mercader, Nadia

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  • Producción científica en acceso abierto de la UAM [17254]

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All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
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