UAM_Biblioteca | Unified search engine | Scientific Production Portal | UAM Research Data Repository
Universidad Autónoma de Madrid
Biblos-e Archivo
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
    • español
    • English
  • English 
    • español
    • English
  • Log in
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search Biblos-e Archivo

Advanced Search

Browse

All of Biblos-e ArchivoCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultiesThis CollectionBy Issue DateAuthorsTitlesSubjectsFaculties

My Account

Log inRegister

Statistics

View Usage Statistics

Help

Information about Biblos-e ArchivoI want to submit my workI want to submit my doctoral thesisFrequently Asked QuestionsCopyrightsFinancial Agencies and OA policy

UAM_Biblioteca

View Item 
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item

The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB

Author
Moreno, Juan A.; Izquierdo, María Concepción; Sánchez-Niño, María Dolores; Suárez-Álvarez, Beatriz; López-Larrea, Carlos; Jakubowski, Aniela; Blanco-Parra, Jualia A.; Ramírez Tapia, Rafael; Selgas Gutiérrez, Rafael; Ruiz-Ortega, Marta; Egido de los Ríos, Jesús; Ortiz Arduán, Albertountranslated; Sanz, Ana Belén
Entity
UAM. Departamento de Medicina
Publisher
American Society of Nephrology
Date
2011-07-01
Citation
10.1681/ASN.2010101073
Journal of the American Society of Nephrology 22.7 (2011): 1315-1325
 
 
 
ISSN
1046-6673 (print); 1533-3450 (online)
DOI
10.1681/ASN.2010101073
Funded by
Grant support: ISCII and FEDER funds CP04/ 00060, PS09/00447, 06/0046, SAF2005–03378, EU QLG1-CT-2002-01215, Sociedad Española de Nefrologia, ISCIIIRETIC REDinREN/RD06/0016, Comunidad de Madrid/CIFRA/SBIO0283/ 2006, Ministerio de Ciencia y Tecnología (SAF2007/63648, PI10/00072), CAM (S2006/ GEN-0247), RECAVA (RD06/0014/0035;) cvREMOD (091100), IRSIN/FRIAT, FIS PI08/0566. Salary support: FIS to J.A.M. (CD05/00083 and CP10/00479), A.S., and M.C.I., MEC to M.D.S.N., Programa Intensificacion Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to A.O
Project
Comunidad de Madrid. S2006/GEN-0247/PROTEOMARKERS
Editor's Version
http://dx.doi.org/10.1681/ASN.2010101073
Subjects
Cytokines; Inflamotory; Cells; Medicina
URI
http://hdl.handle.net/10486/667335
Rights
© 2011 by the American Society of Nephrology

Abstract

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, including vascular injury and renal injury. Whether proinflammatory cytokines, such as TNF and TNF-like weak inducer of apoptosis (TWEAK), modulate Klotho is unknown. In mice, exogenous administration of TWEAK decreased expression of Klotho in the kidney. In the setting of acute kidney injury induced by folic acid, the blockade or absence of TWEAK abrogated the injury-related decrease in renal and plasma Klotho levels. TWEAK, TNF , and siRNA-mediated knockdown of I B all activated NF B and reduced Klotho expression in the MCT tubular cell line. Furthermore, inhibition of NF B with parthenolide prevented TWEAK- or TNF -induced downregulation of Klotho. Inhibition of histone deacetylase reversed TWEAKinduced downregulation of Klotho, and chromatin immunoprecipitation showed that TWEAK promotes RelA binding to the Klotho promoter, inducing its deacetylation. In conclusion, inflammatory cytokines, such as TWEAK and TNF , downregulate Klotho expression through an NF B-dependent mechanism. These results may partially explain the relationship between inflammation and diseases characterized by accelerated aging of organs, including CKD.
Show full item record

Files in this item

Thumbnail
Name
inflammatory_moreno_JASN_2011.pdf
Size
631.4Kb
Format
PDF

Refworks Export

Delicious Save this on Delicious

Google™ Scholar:Moreno, Juan A. - Izquierdo, María Concepción - Sánchez-Niño, María Dolores - Suárez-Álvarez, Beatriz - López-Larrea, Carlos - Jakubowski, Aniela - Blanco-Parra, Jualia A. - Ramírez Tapia, Rafael - Selgas Gutiérrez, Rafael - Ruiz-Ortega, Marta - Egido de los Ríos, Jesús - Ortiz Arduán, Alberto - Sanz, Ana Belén

This item appears in the following Collection(s)

  • Producción científica en acceso abierto de la UAM [15094]

Related items

Showing items related by title, author, creator and subject.

  • Inflammatory cytokines and survival factors from serum modulate tweak-induced apoptosis in PC-3 Prostate Cancer Cells 

    Sanz, Ana Belén; Sánchez-Niño, María Dolores; Carrasco, Susana; Manzarbeitia, Félix; Ruíz Andrés, Olga; Selgas, Rafael; Ruíz-Ortega, Marta; González-Enguita, Carmen; Egido, Jesús; Ortíz, Alberto
    2012-10-15
  • TWEAK promotes peritoneal inflammation 

    Sanz, Ana Belén; Stark Aroeira, Luiz; Bellón, Teresa; Peso, Gloria del; Jiménez-Heffernan, José; Santamaría, Beatríz; Sánchez-Niño, María Dolores; Blanco-Colio, Luis Miguel; López-Cabrera, Manuel; Ruíz-Ortega, Marta; Egido, Jesús; Selgas, Rafael; Ortíz, Alberto
    2014-03-05
  • Tenofovir nephrotoxicity: 2011 update 

    Fernández-Fernández, Beatriz; Montoya-Ferrer, Ana; Sanz, Ana Belén; Sánchez-Niño, María Dolores; Izquierdo, María C.; Poveda, Jonay; Sainz-Prestel, Valeria; Ortíz-Martín, Natalia; Parra-Rodríguez, Alejandro; Selgas, Rafael; Ruíz-Ortega, Marta; Egido, Jesús; Ortíz, Alberto
    2011-12-01
All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
 

 

All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram