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dc.contributor.authorPenela Márquez, Petronila 
dc.contributor.authorNogués, Laura
dc.contributor.authorMayor Menéndez, Federico 
dc.contributor.otherUAM. Departamento de Biología Moleculares_ES
dc.date.accessioned2015-07-27T10:16:18Z
dc.date.available2015-07-27T10:16:18Z
dc.date.issued2014-04-01
dc.identifier.citationCurrent Opinion In Cell Biology 27.1 (2014): 10-17en_US
dc.identifier.issn0955-0674 (print)es_ES
dc.identifier.issn1879-0410 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/667575
dc.description.abstractG protein-coupled receptor kinases (GRKs) are emerging as important integrative nodes in cell migration processes. Recent evidence links GRKs (particularly the GRK2 isoform) to the complex modulation of diverse aspects of cell motility. In addition to its well-established role in the desensitization of G protein-coupled receptors involved in chemotaxis, GRK2 can play a effector role in the organization of actin and microtubule networks and in adhesion dynamics, by means of novel substrates and transient interacting partners, such as the GIT-1 scaffold or the cytoplasmic α-tubulin deacetylase histone deacetylase 6 (HDAC6). The overall effect of altering GRK levels or activity on chemotaxis would depend on how such different roles are integrated in a given cell type and physiological context, and may have relevant implications in inflammatory diseases or cancer progressionen_US
dc.description.sponsorshipOur laboratory is funded by grants from Ministerio de Educación y Ciencia (SAF2011-23800), Fundación Ramón Areces, The Cardiovascular Network (RECAVA) of Ministerio Sanidad y Consumo-Instituto Carlos III (RD12/0042/0012), Comunidad de Madrid Indisnet Network (S2011/BMD-2332) to F.M, and Fundación Eugenio Rodriguez Pascual, Fundación Ramón Areces and Instituto de Salud Carlos III (PI11/00859) to P.P.en_US
dc.format.extent25 pag.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevier Inc.en_US
dc.relation.ispartofCurrent Opinion in Cell Biologyen_US
dc.rights© 2014 Elselvier Inc.en_US
dc.subject.otherCellsen_US
dc.subject.otherCell differentiationen_US
dc.titleRole of G protein-coupled receptor kinases in cell migrationen_US
dc.typearticleen
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.ceb.2013.10.005es_ES
dc.identifier.doi10.1016/j.ceb.2013.10.005es_ES
dc.identifier.publicationfirstpage10es_ES
dc.identifier.publicationissue1es_ES
dc.identifier.publicationlastpage17es_ES
dc.identifier.publicationvolume27es_ES
dc.relation.projectIDComunidad de Madrid. S2010/BMD-2332/INDISNETes_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.ccReconocimiento – NoComercial – SinObraDerivadaes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMMayor Menendez, Federico (260516)
dc.authorUAMNogues Vera, Laura (264281)
dc.authorUAMPenela Márquez, Petronila (260945)
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMCentro de Biología Molecular Severo Ochoa (CBMSO)
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa)


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