Clinical and polysomnographic predictors of the Natural History of poor sleep in the general population
Entity
UAM. Departamento de PsiquiatríaPublisher
American Academy of Sleep MedicineDate
2012Citation
10.5665/sleep.1832
Sleep 35.5 (2012): 689-697
ISSN
0161-8105 (print); 1550-9109 (online)DOI
10.5665/sleep.1832Funded by
This research was funded in part by the National Institutes of Health grants RO1 51931, RO1 40916 (to Dr. Bixler), and RO1 64415 (to Dr. Vgontzas).Editor's Version
http://dx.doi.org/10.5665/sleep.1832Subjects
Incidence; Persistence; Poor sleep; Chronic insomnia; Polysomnography; MedicinaRights
© 2012 Associated Professional Sleep SocietiesAbstract
Study Objectives: Approximately 8-10% of the general population suffers from chronic insomnia, whereas another 20-30% of the population has
insomnia symptoms at any given time (i.e., poor sleep). However, few longitudinal studies have examined risk factors of the natural history of poor
sleep, and none have examined the role of polysomnographic (PSG) variables.
Design: Representative longitudinal study.
Setting: Sleep laboratory.
Participants: From a random, general population sample of 1,741 individuals of the adult Penn State Cohort, 1,395 were followed up after 7.5 yr.
Measurements: Full medical evaluation and 1-night PSG at baseline and telephone interview at follow-up.
Results: The rate of incident poor sleep was 18.4%. Physical (e.g., obesity, sleep apnea, and ulcer) and mental (e.g., depression) health conditions
and behavioral factors (e.g., smoking and alcohol consumption) increased the odds of incident poor sleep as compared to normal sleep. The rates
of persistent, remitted, and poor sleepers who developed chronic insomnia were 39%, 44%, and 17%, respectively. Risk factors for persistent poor
sleep were physical health conditions combined with psychologic distress. Shorter objective sleep duration and a family history of sleep problems
were risk factors for poor sleep evolving into chronic insomnia.
Conclusions: Poor sleep appears to be primarily a symptom of physical and mental health conditions, whereas the persistence of poor sleep is
associated with psychologic distress. Importantly, sleep apnea appears to be associated with incident poor sleep but not with chronic insomnia.
Finally, this study suggests that objective short sleep duration in poor sleepers is a biologic marker of genetic predisposition to chronic insomnia
Files in this item
Google Scholar:Fernandez-Mendoza, Julio
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Vgontzas, Alexandros N.
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Bixler, Edward O.
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Singareddy, Ravi
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Shaffer, Michele L.
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Calhoun, Susan L.
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Karataraki, Maria
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Vela Bueno, Antonio
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Liao, Duanping
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