Lipid transport and metabolism in healthy and osteoarthritic cartilage
Entity
UAM. Departamento de MedicinaPublisher
MDPI AGDate
2013-10-16Citation
10.3390/ijms141020793
International Journal of Molecular Sciences 14.10 (2013): 20793-20808
ISSN
1661-6596 (print); 1422-0067 (online)DOI
10.3390/ijms141020793Funded by
This work was supported by research grants from Fondo de Investigación Sanitaria (FIS) (PS09/01625 and PI12/00144). Amanda Villalvilla is the recipient of a fellowship from the Fundación Conchita Rábago. Rodolfo Gómez is the recipient of a Sara Borrell contract from FIS. Raquel Largo’s work was funded by the Instituto de Salud Carlos III through a research staff stabilization programEditor's Version
http://dx.doi.org/10.3390/ijms141020793Subjects
Cartilage; Cholesterol; Chondrocyte; Lipid; Nutrition; Osteoarthritis; MedicinaRights
© 2013 by the authorsAbstract
Cartilage is an avascular tissue and cartilage metabolism depends on molecule
diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited
by matrix permeability according to the size and charge of the molecules. Matrix
composition limits the access of molecules to chondrocytes, determining cell metabolism
and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and
are available for these cells through de novo synthesis but also through diffusion from
surrounding tissues. Cartilage status and osteoarthritis development depend on lipid
availability. This paper reviews lipid transport and metabolism in cartilage. We also
analyze signalling pathways directly mediated by lipids and those that involve mTOR
pathways, both in normal and osteoarthritic cartilage
Files in this item
Google Scholar:Villalvilla, Amanda
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Gómez, Rodolfo
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Largo, Raquel
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Herrero-Beaumont Cuenca, Gabriel
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