Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
EntityUAM. Departamento de Biología
PublisherThe Royal Society of Chemistry
10.1039/C4CC05867DChemical Communications 50.81 (2014): 12150-12153
ISSN1359-7345 (print); 1364-548X (online)
Funded byJ.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support. J.A.C., P.F., G.L. and R.N. are grateful for the support from (NSERC) Canada.
SubjectsBenzoic acid derivative; Macrocyclic compound; Nanoparticle; Phenyl group; Porphyrin; Pyrrole derivative; Singlet oxygen; Biología y Biomedicina / Biología
Rights© the Partner Organisations 2014; © The Royal Society of Chemistry 2014
LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation
Google Scholar:Yu, Q. - Rodriguez, E. M. - Naccache, R. - Forgione, P. - Lamoureux, G. - Sanz Rodríguez, Francisco - Scheglmann, D. - Capobianco, J. A.
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