Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
Entity
UAM. Departamento de BiologíaPublisher
The Royal Society of ChemistryDate
2014-10-18Citation
10.1039/C4CC05867D
Chemical Communications 50.81 (2014): 12150-12153
ISSN
1359-7345 (print); 1364-548X (online)DOI
10.1039/C4CC05867DFunded by
J.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support. J.A.C., P.F., G.L. and R.N. are grateful for the support from (NSERC) Canada.Editor's Version
http://dx.doi.org/10.1039/C4CC05867DSubjects
Benzoic acid derivative; Macrocyclic compound; Nanoparticle; Phenyl group; Porphyrin; Pyrrole derivative; Singlet oxygen; Biología y Biomedicina / BiologíaRights
© the Partner Organisations 2014; © The Royal Society of Chemistry 2014Abstract
LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second
generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation
Files in this item
Google Scholar:Yu, Q.
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Rodriguez, E. M.
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Naccache, R.
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Forgione, P.
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Lamoureux, G.
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Sanz Rodríguez, Francisco
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Scheglmann, D.
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Capobianco, J. A.
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