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Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

Author
Yu, Q.; Rodriguez, E. M.; Naccache, R.; Forgione, P.; Lamoureux, G.; Sanz Rodríguez, Franciscountranslated; Scheglmann, D.; Capobianco, J. A.
Entity
UAM. Departamento de Biología
Publisher
The Royal Society of Chemistry
Date
2014-10-18
Citation
Chemical Communications 50.81 (2014): 12150-12153
ISSN
1359-7345 (print); 1364-548X (online)
DOI
10.1039/C4CC05867D
Funded by
J.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support. J.A.C., P.F., G.L. and R.N. are grateful for the support from (NSERC) Canada.
Editor's Version
http://dx.doi.org/10.1039/C4CC05867D
Subjects
Benzoic acid derivative; Macrocyclic compound; Nanoparticle; Phenyl group; Porphyrin; Pyrrole derivative; Singlet oxygen; Biología y Biomedicina / Biología
URI
http://hdl.handle.net/10486/670716
Rights
© the Partner Organisations 2014; © The Royal Society of Chemistry 2014

Abstract

LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation
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Google™ Scholar:Yu, Q. - Rodriguez, E. M. - Naccache, R. - Forgione, P. - Lamoureux, G. - Sanz Rodríguez, Francisco - Scheglmann, D. - Capobianco, J. A.

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