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Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

Autor (es)
Yu, Q.; Rodriguez, E. M.; Naccache, R.; Forgione, P.; Lamoureux, G.; Sanz Rodríguez, FranciscoAutoridad UAM; Scheglmann, D.; Capobianco, J. A.
Entidad
UAM. Departamento de Biología
Editor
The Royal Society of Chemistry
Fecha de edición
2014-10-18
Cita
Chemical Communications 50.81 (2014): 12150-12153
ISSN
1359-7345 (print); 1364-548X (online)
DOI
10.1039/C4CC05867D
Financiado por
J.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support. J.A.C., P.F., G.L. and R.N. are grateful for the support from (NSERC) Canada.
Versión del editor
http://dx.doi.org/10.1039/C4CC05867D
Materias
Benzoic acid derivative; Macrocyclic compound; Nanoparticle; Phenyl group; Porphyrin; Pyrrole derivative; Singlet oxygen; Biología y Biomedicina / Biología
URI
http://hdl.handle.net/10486/670716
Derechos
© the Partner Organisations 2014; © The Royal Society of Chemistry 2014

Resumen

LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation
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Google™ Scholar:Yu, Q. - Rodriguez, E. M. - Naccache, R. - Forgione, P. - Lamoureux, G. - Sanz Rodríguez, Francisco - Scheglmann, D. - Capobianco, J. A.

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