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Chemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

dc.contributor.authorYu, Q.
dc.contributor.authorRodriguez, E. M.
dc.contributor.authorNaccache, R.
dc.contributor.authorForgione, P.
dc.contributor.authorLamoureux, G.
dc.contributor.authorSanz Rodríguez, Francisco 
dc.contributor.authorScheglmann, D.
dc.contributor.authorCapobianco, J. A.
dc.contributor.otherUAM. Departamento de Biologíaes_ES
dc.date.accessioned2016-04-21T10:19:00Z
dc.date.available2016-04-21T10:19:00Z
dc.date.issued2014-10-18
dc.identifier.citationChemical Communications 50.81 (2014): 12150-12153en_US
dc.identifier.issn1359-7345 (print)es_ES
dc.identifier.issn1364-548X (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/670716
dc.description.abstractLiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiationen_US
dc.description.sponsorshipJ.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support. J.A.C., P.F., G.L. and R.N. are grateful for the support from (NSERC) Canada.en_US
dc.format.extent4 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherThe Royal Society of Chemistryen_US
dc.relation.ispartofChemical Communicationsen_US
dc.rights© the Partner Organisations 2014en_US
dc.rights© The Royal Society of Chemistry 2014en_US
dc.subject.otherBenzoic acid derivativeen_US
dc.subject.otherMacrocyclic compounden_US
dc.subject.otherNanoparticleen_US
dc.subject.otherPhenyl groupen_US
dc.subject.otherPorphyrinen_US
dc.subject.otherPyrrole derivativeen_US
dc.subject.otherSinglet oxygenen_US
dc.titleChemical modification of temoporfin - A second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generationen_US
dc.typearticleen
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C4CC05867Des_ES
dc.identifier.doi10.1039/C4CC05867Des_ES
dc.identifier.publicationfirstpage12150es_ES
dc.identifier.publicationissue81es_ES
dc.identifier.publicationlastpage12153es_ES
dc.identifier.publicationvolume50es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Ciencias


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