Differential profile in inflammatory and mineral metabolism biomarkers in patients with ischemic heart disease without classical coronary risk factors
Author
Pello, Ana María; Cristóbal, Carmen; Tarín, Nieves; Huelmos, Ana; Aceña Navarro, Álvaro



Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
Elsevier Inc; Japanese College of CardiologyDate
2016-01-01Citation
10.1016/j.jjcc.2014.11.006
Journal of Cardiology 66.1 (2015): 22-7
ISSN
0914-5087; 1876-4738 (on line)DOI
10.1016/j.jjcc.2014.11.006Funded by
This work was supported by grants from Fondo de Investigaciones Sanitarias (PI05/0451, PI05/1497, PI05/52475, PI05/1043, PS09/01405, and PI10/00072); Spanish Society of Cardiology; Spanish Heart Foundation; Spanish Society of Arteriosclerosis; RECAVA (RD06/0014/0035); Fundación Lilly; Instituto de Salud Carlos III FEDER (FJD Biobank: RD09/0076/00101); and AbbVie LaboratoriesEditor's Version
http://dx.doi.org/10.1016/j.jjcc.2014.11.006Subjects
Atherosclerosis; Biomarkers; Cardiovascular risk factors; Fibroblast growth factor-23; Monocyte chemoattractant protein-1; MedicinaRights
© 2014 Japanese College of CardiologyAbstract
BACKGROUND
Patients with coronary heart disease (CHD) without classical cardiovascular risk factors (CRF) are uncommon, and their profile has not been thoroughly studied. In CHD patients, we have assessed the differences in several biomarkers between those with and without CRF.
METHODS
We studied 704 patients with CHD, analyzing plasma levels of biomarkers related to inflammation, thrombosis, renal damage, and heart failure: hs-CRP (high-sensitivity C-reactive protein), MCP-1 (monocyte chemoattractant protein-1), galectin-3, NT-pro-BNP (N-terminal fragment of brain natriuretic peptide), calcidiol (vitamin D metabolite), fibroblast growth factor-23 (FGF-23), parathormone, and phosphate.
RESULTS
Twenty patients (2.8%) exhibited no CRFs. Clinical variables were well balanced in both groups, with the logical exceptions of no use of antidiabetic drugs, lower triglyceride and glucose, and higher high-density lipoprotein cholesterol in no-CRF patients.
No-CRF patients showed lower hs-CRP (2.574±3.120 vs 4.554±9.786 mg/L; P=0.018), MCP-1 (114.75±36.29 vs 143.56±65.37 pg/ml; P=0.003) and FGF-23 (79.28±40.22 vs 105.17±156.61 RU/ml; P=0.024) and higher calcidiol (23.66±9.12 vs 19.49±8.18 ng/ml; P=0.025) levels. At follow-up, 10.0% vs 11.0% patients experienced acute ischemic event, heart failure, or death in the non-CRF and CRF groups, respectively (P=0.815, log-rank test). The limited number of non-CRF patients may have influenced this finding. A Cox regression analysis in the whole population showed that high calcidiol, and low MCP-1 and FGF-23 plasma levels are associated to a better prognosis.
CONCLUSIONS
CHD patients without CRFs show a favorable biomarker profile in terms of inflammation and mineral metabolism. Further studies are needed to investigate whether this difference translates into a better prognosis.
Files in this item
Google Scholar:Pello, Ana María
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Cristóbal, Carmen
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Tarín, Nieves
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Huelmos, Ana
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Aceña Navarro, Álvaro
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Carda, Rocío
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González-Casaus, María Luisa
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Alonso, Joaquín
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Lorenzo González, Óscar
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Blanco-Colio, Luis
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Martín Ventura, José Luis
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Franco Peláez, Juan Antonio
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Mahillo, Ignacio
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Farré, Jerónimo
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López-Bescós, Lorenzo
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Egido, Jesús
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Tuñón Fernández, José Luis
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