Differential profile in inflammatory and mineral metabolism biomarkers in patients with ischemic heart disease without classical coronary risk factors

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dc.contributor.author Pello, Ana María
dc.contributor.author Cristóbal, Carmen
dc.contributor.author Tarín, Nieves
dc.contributor.author Huelmos, Ana
dc.contributor.author Aceña, Álvaro
dc.contributor.author Carda, Rocío
dc.contributor.author González-Casaus, María Luisa
dc.contributor.author Alonso, Joaquín
dc.contributor.author Lorenzo, Óscar
dc.contributor.author Blanco-Colio, Luis
dc.contributor.author Martín-Ventura, José Luis
dc.contributor.author Franco Peláez, Juan Antonio
dc.contributor.author Mahillo, Ignacio
dc.contributor.author Farré, Jerónimo
dc.contributor.author López-Bescós, Lorenzo
dc.contributor.author Egido, Jesús
dc.contributor.author Tuñón, José
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) es_ES
dc.date.accessioned 2016-05-30T13:37:37Z
dc.date.available 2016-05-30T13:37:37Z
dc.date.issued 2016-01-01
dc.identifier.citation Journal of Cardiology 66.1 (2015): 22-7 es_ES
dc.identifier.issn 0914-5087 es_ES
dc.identifier.issn 1876-4738 (on line) es_ES
dc.identifier.uri http://hdl.handle.net/10486/671134
dc.description.abstract BACKGROUND Patients with coronary heart disease (CHD) without classical cardiovascular risk factors (CRF) are uncommon, and their profile has not been thoroughly studied. In CHD patients, we have assessed the differences in several biomarkers between those with and without CRF. METHODS We studied 704 patients with CHD, analyzing plasma levels of biomarkers related to inflammation, thrombosis, renal damage, and heart failure: hs-CRP (high-sensitivity C-reactive protein), MCP-1 (monocyte chemoattractant protein-1), galectin-3, NT-pro-BNP (N-terminal fragment of brain natriuretic peptide), calcidiol (vitamin D metabolite), fibroblast growth factor-23 (FGF-23), parathormone, and phosphate. RESULTS Twenty patients (2.8%) exhibited no CRFs. Clinical variables were well balanced in both groups, with the logical exceptions of no use of antidiabetic drugs, lower triglyceride and glucose, and higher high-density lipoprotein cholesterol in no-CRF patients. No-CRF patients showed lower hs-CRP (2.574±3.120 vs 4.554±9.786 mg/L; P=0.018), MCP-1 (114.75±36.29 vs 143.56±65.37 pg/ml; P=0.003) and FGF-23 (79.28±40.22 vs 105.17±156.61 RU/ml; P=0.024) and higher calcidiol (23.66±9.12 vs 19.49±8.18 ng/ml; P=0.025) levels. At follow-up, 10.0% vs 11.0% patients experienced acute ischemic event, heart failure, or death in the non-CRF and CRF groups, respectively (P=0.815, log-rank test). The limited number of non-CRF patients may have influenced this finding. A Cox regression analysis in the whole population showed that high calcidiol, and low MCP-1 and FGF-23 plasma levels are associated to a better prognosis. CONCLUSIONS CHD patients without CRFs show a favorable biomarker profile in terms of inflammation and mineral metabolism. Further studies are needed to investigate whether this difference translates into a better prognosis. es_ES
dc.description.sponsorship This work was supported by grants from Fondo de Investigaciones Sanitarias (PI05/0451, PI05/1497, PI05/52475, PI05/1043, PS09/01405, and PI10/00072); Spanish Society of Cardiology; Spanish Heart Foundation; Spanish Society of Arteriosclerosis; RECAVA (RD06/0014/0035); Fundación Lilly; Instituto de Salud Carlos III FEDER (FJD Biobank: RD09/0076/00101); and AbbVie Laboratories es_ES
dc.format.extent 16 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso spa es_ES
dc.publisher Elsevier Inc es_ES
dc.publisher Japanese College of Cardiology es_ES
dc.relation.ispartof Journal of Cardiology es_ES
dc.rights © 2014 Japanese College of Cardiology es_ES
dc.subject.other Atherosclerosis es_ES
dc.subject.other Biomarkers es_ES
dc.subject.other Cardiovascular risk factors es_ES
dc.subject.other Fibroblast growth factor-23 es_ES
dc.subject.other Monocyte chemoattractant protein-1 es_ES
dc.title Differential profile in inflammatory and mineral metabolism biomarkers in patients with ischemic heart disease without classical coronary risk factors es_ES
dc.type article es_ES
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.jjcc.2014.11.006 es_ES
dc.identifier.doi 10.1016/j.jjcc.2014.11.006 es_ES
dc.identifier.publicationfirstpage 22 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 27 es_ES
dc.identifier.publicationvolume 66 es_ES
dc.type.version info:eu-repo/semantics/draft es_ES
dc.rights.accessRights openAccess es_ES
dc.authorUAM Aceña Navarro, Álvaro (279732)
dc.authorUAM Tuñón Fernández, José Luis (258858)

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