Adipose tissue-derived mesenchymal stem cells as a strategy to improve recovery after stroke
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
Informa HealthcareDate
2015-06-01Citation
10.1517/14712598.2015.1040386
Expert Opinion on Biological Therapy 15.6 (2015): 873-81
ISSN
1471-2598; 1744-7682 (on line)DOI
10.1517/14712598.2015.1040386Funded by
This project is supported by research grants PS12/01754 (Spanish Ministry of Science) and INVICTUS (RD12/0014/0006) (Spanish Neurovascular Network), and Research Institute Carlos III, Ministry Science and InnovationProject
Gobierno de España. PS12/01754Editor's Version
http://dx.doi.org/10.1517/14712598.2015.1040386Subjects
Adipose tissue; Hemorrhagic stroke; Ischemic stroke; Mesenchymal stem cells; MedicinaAbstract
Introduction: Based on the positive results observed in experimental animal models, adipose
tissue-derived mesenchymal stem cells (AD-MSCs) constitute a promising therapy for stroke
treatment. However, several aspects need to be clarified to identify the optimal conditions for
successful clinical translation.
Areas covered: This review focuses on AD-MSC treatment for ischemic and hemorrhagic stroke
in experimental animal models. In addition, we will explore the optimization of treatment
conditions including AD-MSC production, administration routes and therapeutic windows for
their appropriate use in patients, and we will provide an update on clinical trials on this
therapy.
Expert opinion: Compared with other cell types, AD-MSCs have been less investigated in
stroke studies. Currently, experimental animal models have shown safety and efficacy with this
treatment after stroke. Due to several advantages of AD-MSCs, such as their abundance and
accessibility, they can be considered a promising strategy for use in patients. However, many
questions are still to be resolved regarding their mechanisms of action, immune system
modulation and the effects of AD-MSCs on all components of the brain that may be affected
after ischemic and hemorrhagic strokes
Files in this item
Google Scholar:Gutiérrez-Fernández, María
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Otero-Ortega, Laura
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Ramos-Cejudo, Jaime
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Rodríguez-Frutos, Berta
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Fuentes Gimeno, Blanca Eulalia
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Díez Tejedor, Exuperio
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