dc.contributor.author | Fernández-Montoya, Julia | |
dc.contributor.author | Pérez, Mar | |
dc.contributor.other | UAM. Departamento de Anatomía, Histología y Neurociencia | es_ES |
dc.date.accessioned | 2016-06-09T13:29:49Z | |
dc.date.available | 2016-06-09T13:29:49Z | |
dc.date.issued | 2015-01-01 | |
dc.identifier.citation | Journal of Alzheimer's Disease 45.1 (2015): 1-14 | en |
dc.identifier.issn | 1387-2877 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/671368 | |
dc.description | The final of publication is available at: http://dx.doi.org/10.3233/JAD-140456 | en_US |
dc.description.abstract | Tauopathies, such as Alzheimer’s disease (AD) and Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by tau accumulation. This accumulation could result from alterations in tau degradation by either the ubiquitin-proteasome system or the autophagy–lysosomal pathway. To analyze a possible alteration of the autophagy–lysosomal pathway in transgenic mice expressing human tau with three FTDP-17 missense mutations (TauVLW mice), we studied the lysosomal enzyme Cathepsin D. The hippocampi of TauVLW mice, where the human mutant tau accumulates, showed both increased Cathepsin D and partial colocalization of Cathepsin D with human mutant tau. At the ultrastructural level, some multivesicular bodies showed human mutant tau-immunopositive vesicles. This finding could provide insights into the molecular mechanisms of tau degradation in human tauopathies | en_US |
dc.description.sponsorship | This study was funded by grant from the Spanish Ministry of Health (SAF 2011-24841) | es_ES |
dc.format.extent | 21 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | IOS Press | es_ES |
dc.relation.ispartof | Journal of Alzheimer's Disease | en |
dc.subject.other | Cathepsin D | es_ES |
dc.subject.other | FTDP-17 | es_ES |
dc.subject.other | Lysosomal system | en_US |
dc.subject.other | Mutated tau | en_US |
dc.title | Cathepsin D in a murine model of frontotemporal dementia with parkinsonism-linked to chromosome 17 | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3233/JAD-140456 | es_ES |
dc.identifier.doi | 10.3233/JAD-140456 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationissue | 1 | es_ES |
dc.identifier.publicationlastpage | 14 | es_ES |
dc.identifier.publicationvolume | 45 | es_ES |
dc.relation.projectID | Gobierno de España. SAF 2011-24841 | es_ES |
dc.type.version | info:eu-repo/semantics/acceptedVersion | en_US |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |