Allergic sensitization, rhinitis and tobacco smoke exposure in US adults

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dc.contributor.author Shargorodsky, Josef
dc.contributor.author Garcia-Esquinas, Esther
dc.contributor.author Galán, Iñaki
dc.contributor.author Navas-Acien, Ana
dc.contributor.author Lin, Sandra Y.
dc.contributor.author Sun, Qinghua
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.date.accessioned 2016-06-15T14:38:04Z
dc.date.available 2016-06-15T14:38:04Z
dc.date.issued 2015-07-14
dc.identifier.citation PLoS ONE 10.7 (2015): e0131957 es_ES
dc.identifier.issn 1932-6203 es_ES
dc.identifier.uri http://hdl.handle.net/10486/671433
dc.description.abstract Introduction Tobacco exposure has been linked with sinonasal pathology and may be associated with allergic sensitization. This study evaluates the association between exposure to active smoking or secondhand smoke (SHS) and the prevalence of rhinitis and allergic sensitization in the US adult population. Methods Cross-sectional study in 4,339 adults aged 20–85 in the National Health and Nutrition Examination Survey, 2005–2006. Never smoking was defined as reported lifetime smoking less than 100 cigarettes and serum cotinine levels <10ng/ml, while active smoking was defined as self-reported smoking or serum cotinine concentrations > 10 ng/mL. Selfreported rhinitis was based on symptoms during the past 12 months, and allergen sensitization was defined as a positive response to any of the 19 specific IgE antigens tested. Results Almost half of the population (43%) had detectable levels of IgE specific to at least one inhaled allergen and 32% reported a history of rhinitis. After multivariate adjustment, there was a statistically significant association between the highest serum cotinine tertile and rhinitis in active smokers (OR 1.42; 95%CI 1.00–2.00). The association between active smoking and rhinitis was stronger in individuals without allergic sensitization (OR 2.47; 95%CI 1.44–4.23). There was a statistically significant association between increasing cotinine tertiles and decreased odds of inhaled allergen sensitization (p-trend <.01). Conclusion Tobacco smoke exposure was associated with increased prevalence of rhinitis symptoms, but not with allergic sensitization. The results indicate that the relationship between tobacco smoke exposure and sinonasal pathology in adults may be independent of allergic sensitization en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Public Library of Science en_US
dc.relation.ispartof PLoS ONE es_ES
dc.rights © 2015 Shargorodsky et al. es_ES
dc.subject.other Tobacco en_US
dc.subject.other Population en_US
dc.subject.other Rhinitis symptoms en_US
dc.title Allergic sensitization, rhinitis and tobacco smoke exposure in US adults en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.abstract Reconocimiento (by) es_ES
dc.relation.publisherversion http://dx.doi.org/10.371/journal.pone.0131957 es_ES
dc.identifier.doi 10.371/journal.pone.0131957 es_ES
dc.identifier.publicationfirstpage 1 es_ES
dc.identifier.publicationissue 7 es_ES
dc.identifier.publicationlastpage 10 es_ES
dc.identifier.publicationvolume 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en_US
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Galán Labaca, Ignacio (262111)


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