dc.contributor.author | Shargorodsky, Josef | |
dc.contributor.author | García García-Esquinas, Esther | |
dc.contributor.author | Galán Labaca, Ignacio | |
dc.contributor.author | Navas-Acien, Ana | |
dc.contributor.author | Lin, Sandra Y. | |
dc.contributor.author | Sun, Qinghua | |
dc.contributor.other | UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología | es_ES |
dc.date.accessioned | 2016-06-15T14:38:04Z | |
dc.date.available | 2016-06-15T14:38:04Z | |
dc.date.issued | 2015-07-14 | |
dc.identifier.citation | PLoS ONE 10.7 (2015): e0131957 | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/671433 | |
dc.description.abstract | Introduction
Tobacco exposure has been linked with sinonasal pathology and may be associated with
allergic sensitization. This study evaluates the association between exposure to active
smoking or secondhand smoke (SHS) and the prevalence of rhinitis and allergic sensitization
in the US adult population.
Methods
Cross-sectional study in 4,339 adults aged 20–85 in the National Health and Nutrition
Examination Survey, 2005–2006. Never smoking was defined as reported lifetime smoking
less than 100 cigarettes and serum cotinine levels <10ng/ml, while active smoking was
defined as self-reported smoking or serum cotinine concentrations > 10 ng/mL. Selfreported
rhinitis was based on symptoms during the past 12 months, and allergen sensitization
was defined as a positive response to any of the 19 specific IgE antigens tested.
Results
Almost half of the population (43%) had detectable levels of IgE specific to at least one
inhaled allergen and 32% reported a history of rhinitis. After multivariate adjustment, there
was a statistically significant association between the highest serum cotinine tertile and rhinitis
in active smokers (OR 1.42; 95%CI 1.00–2.00). The association between active smoking
and rhinitis was stronger in individuals without allergic sensitization (OR 2.47; 95%CI
1.44–4.23). There was a statistically significant association between increasing cotinine tertiles
and decreased odds of inhaled allergen sensitization (p-trend <.01).
Conclusion
Tobacco smoke exposure was associated with increased prevalence of rhinitis symptoms,
but not with allergic sensitization. The results indicate that the relationship between tobacco
smoke exposure and sinonasal pathology in adults may be independent of allergic
sensitization | en_US |
dc.format.extent | 10 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLoS ONE | es_ES |
dc.rights | © 2015 Shargorodsky et al. | es_ES |
dc.subject.other | Tobacco | en_US |
dc.subject.other | Population | en_US |
dc.subject.other | Rhinitis symptoms | en_US |
dc.title | Allergic sensitization, rhinitis and tobacco smoke exposure in US adults | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.abstract | Reconocimiento (by) | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.371/journal.pone.0131957 | es_ES |
dc.identifier.doi | 10.371/journal.pone.0131957 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationissue | 7 | es_ES |
dc.identifier.publicationlastpage | 10 | es_ES |
dc.identifier.publicationvolume | 10 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en_US |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Galán Labaca, Ignacio (262111) | |
dc.facultadUAM | Facultad de Medicina | |