Enantioselective synthesis of cyclobutylboronates via a copper-catalyzed desymmetrization approach
Entity
UAM. Departamento de Química OrgánicaPublisher
Wiley - V C H Verlag GmbH & Co. KGaADate
2016-05-09Citation
10.1002/ange.201601976
Angewandte Chemie 128. 24 (2016): 7083–7086
ISSN
1521-3757DOI
10.1002/ange.201601976Funded by
We thank the European Research Council (ERC-337776) and MINECO (CTQ2012-35957) for financial support. M. T. and A. P. thank MICINN for RyC and JdC contractsProject
info:eu-repo/grantAgreement/EC/FP7/337776; Gobierno de España. CTQ2012-35957Editor's Version
http://dx.doi.org/10.1002/ange.201601976Subjects
Asymmetric catalysis; Cyclobutanes; Boron; Copper; QuímicaNote
This is the peer reviewed version of the following article: Guisán-Ceinos, M., Parra, A., Martín-Heras, V. and Tortosa, M. (2016), Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach. Angew. Chem., which has been published in final form at http://dx.doi.org/10.1002/ange.201601976. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Rights
© 1999 - 2016 John Wiley & Sons, IncAbstract
In this report, the first catalytic enantioselective synthesis
of cyclobutylboronates, using a chiral copper(I) complex, is disclosed.
A broad variety of cyclobutanes have been prepared with
consistently high levels of diastereo- and enantiocontrol. Moreover,
this method constitutes the first report of an enantioselective
desymmetrization of meso-cyclobutenes to prepare chiral
cyclobutanes
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Google Scholar:Guisán-Ceinos, M.
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Parra Alfambra, Ana María
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Martín-Heras, Víctor
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Tortosa Manzanares, Mariola
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