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dc.contributor.authorSastre, Esther
dc.contributor.authorBlanco Rivero, Javier 
dc.contributor.authorCaracuel, Laura
dc.contributor.authorCallejo, María
dc.contributor.authorBalfagón, Gloria
dc.contributor.otherUAM. Departamento de Fisiologíaes_ES
dc.contributor.otherInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)es_ES
dc.date.accessioned2016-06-20T13:40:01Z
dc.date.available2016-06-20T13:40:01Z
dc.date.issued2015-05-07
dc.identifier.citationPlLos ONE 10.5 (2015): e0126017en_US
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/10486/671558
dc.description.abstractBackground and Purpose We investigated whether pregnancy was associated with changed function in components of perivascular mesenteric innervation and the mechanism/s involved. Experimental Approach We used superior mesenteric arteries from female Sprague-Dawley rats divided into two groups: control rats (in oestrous phase) and pregnant rats (20 days of pregnancy). Modifications in the vasoconstrictor response to electrical field stimulation (EFS) were analysed in the presence/absence of phentolamine (alpha-adrenoceptor antagonist) or L-NAME (nitric oxide synthase-NOS- non-specific inhibitor). Vasomotor responses to noradrenaline (NA), and to NO donor DEA-NO were studied, NA and NO release measured and neuronal NOS (nNOS) expression/activation analysed. Key Results EFS induced a lower frequency-dependent contraction in pregnant than in control rats. Phentolamine decreased EFS-induced vasoconstriction in segments from both experimental groups, but to a greater extent in control rats. EFS-induced vasoconstriction was increased by L-NAME in arteries from both experimental groups. This increase was greater in segments from pregnant rats. Pregnancy decreased NA release while increasing NO release. nNOS expression was not modified but nNOS activation was increased by pregnancy. Pregnancy decreased NA-induced vasoconstriction response and did not modify DEANO- induced vasodilation responseen_US
dc.description.sponsorshipThis study was supported by Ministerio de Economía y Competitividad (SAF2012-38530), Red RIC (RD12/0042/0024), and Fundación MAPFRE. E. Sastre received a FPI-UAM fellowship. L. Caracuel received a fellowship from Alianza 4 Universidades Program.en_US
dc.format.extent18 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONEen_US
dc.rights© 2015 Sastre et al.es_ES
dc.subject.otherPregnancyen_US
dc.subject.otherMesenteric arteriesen_US
dc.subject.otherEFSen_US
dc.titleAlterations in perivascular sympathetic and nitrergic innervation function induced by late pregnancy in rat mesenteric arteriesen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0126017es_ES
dc.identifier.doi10.1371/journal.pone.0126017en
dc.identifier.publicationfirstpage1es_ES
dc.identifier.publicationissue5es_ES
dc.identifier.publicationlastpage18es_ES
dc.identifier.publicationvolume10es_ES
dc.relation.projectIDGobierno de España. SAF2012-38530es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMSastre Gil, Esther (264491)
dc.facultadUAMFacultad de Medicina
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)


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