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Galactomannan downregulates the inflammation responses in human macrophages via NF κ B2/p100

Author
Toledano, Víctor; Hernández-Jiménez, Enrique; Cubillos-Zapata, Carolina; Flandez, Marta; Álvarez, Enrique; Varela-Serrano, Aníbal; Cantero, Ramón; Valles, Gema; García-Rio, Francisco; López-Collazo, Eduardo
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
Publisher
Hindawi Publishing Corporation
Date
2015-01-01
Citation
10.1155/2015/942517
Mediators of Inflammation 2015 (2015): ID 942517
 
 
 
ISSN
0962-9351
DOI
10.1155/2015/942517
Funded by
They would also like to acknowledge the Fondo de Investigación Sanitaria grant awarded to ELC
Editor's Version
http://dx.doi.org/10.1155/2015/942517
Subjects
Galactomannan; Cells; Modulator of inflammatory; Medicina
URI
http://hdl.handle.net/10486/672158
Rights
© 2015 Víıctor Toledano et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

We show that galactomannan, a polysaccharide consisting of amannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NF𝜅B2)/p100 was overexpressed after galactomannan challenge. Knocking down NF𝜅B2/p100 using small interfering RNA (siRNA) indicated that NF𝜅B2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required.
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Google™ Scholar:Toledano, Víctor - Hernández-Jiménez, Enrique - Cubillos-Zapata, Carolina - Flandez, Marta - Álvarez, Enrique - Varela-Serrano, Aníbal - Cantero, Ramón - Valles, Gema - García-Rio, Francisco - López-Collazo, Eduardo

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  • Producción científica en acceso abierto de la UAM [15083]

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