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N-terminal pro-brain natriuretic peptide is associated with a future diagnosis of cancer in patients with coronary artery disease

Author
Tuñón Fernández, José Luisuntranslated; Higueras, Javier; Tarín, Nieves; Cristóbal, Carmen; Lorenzo González, Óscaruntranslated; Blanco-Colio, Luis; Martín Ventura, José Luisuntranslated; Huelmos, Ana; Alonso, Joaquín; Aceña Navarro, Álvarountranslated; Pello, Ana María; Carda, Rocío; Asensio, Dolores; Mahillo, Ignacio; López Bescós, Lorenzo; Egido, Jesús; Farré, Jerónimo
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
Publisher
Public Library of Science
Date
2015-06-05
Citation
10.1371/journal.pone.0126741
PLOS ONE 10.6 (2015); e0126741
 
 
 
ISSN
1932-6203
DOI
10.1371/journal.pone.0126741
Funded by
This work was supported by grants from Fondo de Investigaciones Sanitarias (PI05/0451, PI05/1497,PI05/2475, PI05/1043, PS09/01405, PI10/ 00072, and PI10/0234, PI14/1567, Programa de Estabilización to LBC); Spanish Society of Cardiology and Spanish Heart Foundation; Spanish Society of Arteriosclerosis; RECAVA (RD06/0014/0035, www. recava.com); Fundación Lilly; and Instituto de Salud Carlos III FEDER (FJD biobank: RD09/0076/00101).
Editor's Version
http://dx.doi.org/10.1371/journal.pone.0126741
Subjects
Natriuretic peptides; Cancer; Coronary artery disease; Medicina
URI
http://hdl.handle.net/10486/672235
Rights
© 2015 Tuñón et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Objective Several papers have reported elevated plasma levels of natriuretic peptides in patients with a previous diagnosis of cancer. We have explored whether N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels predict a future diagnosis of cancer in patients with coronary artery disease (CAD). Methods We studied 699 patients with CAD free of cancer. At baseline, NT-proBNP, galectin-3, monocyte chemoattractant protein-1, soluble tumor necrosis factor-like weak inducer of apoptosis, high-sensitivity C-reactive protein, and high-sensitivity cardiac troponin I plasma levels were assessed. The primary outcome was new cancer diagnosis. The secondary outcome was cancer diagnosis, heart failure requiring hospitalization, or death. Results After 2.15±0.98 years of follow-up, 24 patients developed cancer. They were older (68.5 [61.5, 75.8] vs 60.0 [52.0, 72.0] years; p=0.011), had higher NT-proBNP (302.0 [134.8, 919.8] vs 165.5 [87.4, 407.5] pg/ml; p=0.040) and high-sensitivity C-reactive protein (3.27 [1.33, 5.94] vs 1.92 [0.83, 4.00] mg/L; p=0.030), and lower triglyceride (92.5 [70.5, 132.8] vs 112.0 [82.0, 157.0] mg/dl; p=0.044) plasma levels than those without cancer. NT-proBNP (Hazard Ratio [HR]=1.030; 95% Confidence Interval [CI]=1.008-1.053; p=0.007) and triglyceride levels (HR=0.987; 95%CI=0.975-0.998; p=0.024) were independent predictors of a new cancer diagnosis (multivariate Cox regression analysis). When patients in whom the suspicion of cancer appeared in the first one-hundred days after blood extraction were excluded, NT-proBNP was the only predictor of cancer (HR=1.061; 95% CI=1.034-1.088; p<0.001). NT-proBNP was an independent predictor of cancer, heart failure, or death (HR=1.038; 95%CI=1.023-1.052; p<0.001) along with age, and use of insulin and acenocumarol. Conclusions NT-proBNP is an independent predictor of malignancies in patients with CAD. New studies in large populations are needed to confirm these findings
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Google™ Scholar:Tuñón Fernández, José Luis - Higueras, Javier - Tarín, Nieves - Cristóbal, Carmen - Lorenzo González, Óscar - Blanco-Colio, Luis - Martín Ventura, José Luis - Huelmos, Ana - Alonso, Joaquín - Aceña Navarro, Álvaro - Pello, Ana María - Carda, Rocío - Asensio, Dolores - Mahillo, Ignacio - López Bescós, Lorenzo - Egido, Jesús - Farré, Jerónimo

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  • Producción científica en acceso abierto de la UAM [17721]

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