Osteoarthritis and frailty in elderly individuals across six European countries: Results from the European Project on OSteoArthritis (EPOSA)
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
BioMed CentralDate
2015-11-17Citation
10.1186/s12891-015-0807-8
BMC Musculoskeletal Disorders 16.1 (2015): 359
ISSN
1471-2474DOI
10.1186/s12891-015-0807-8Funded by
The study was supported by a non-commercial private funder. The Indicators for Monitoring COPD and Asthma - Activity and Function in the Elderly in Ulm study (IMCA - ActiFE) was supported by the European Union (No.: 2005121) and the Ministry of Science, Baden-Württemberg. The Italian cohort study is part of the National Research Council Project on Aging (PNR). The Longitudinal Aging Study Amsterdam (LASA) is financially supported by the Dutch Ministry of Health, Welfare and Sports. The Peñagrande study was partially supported by the National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain (project numbers FIS PI 05/1898; FIS RETICEF RD06/0013/1013 and FIS PS09/02143). The Swedish Twin Registry is supported in part by the Swedish Ministry of Higher Education. The Hertfordshire Cohort Study is funded by the Medical Research Council of Great Britain, Arthritis Research UK, the British Heart Foundation and the International Osteoporosis Foundation.Project
info:eu-repo/grantAgreement/EC/FP7/2005121Editor's Version
http://dx.doi.org/10.1186/s12891-015-0807-8Subjects
European; Older people; Osteoarthritis; Frailty; Prevalence; MedicinaRights
© 2015 Castell et al.Abstract
Background: Osteoarthritis (OA) is the most common cause of disability in the elderly. Clinical frailty is associated with
high mortality, but few studies have explored the relationship between OA and frailty.
The objective of this study was to consider the association between OA and frailty/pre-frailty in an elderly population
comprised of six European cohorts participating in the EPOSA project.
Methods: Longitudinal study using baseline data and first follow-up waves, from EPOSA; 2,455 individuals aged 65-85
years were recruited from pre-existing population-based cohorts in Germany, Italy, the Netherlands, Spain, Sweden and
the United Kingdom. Data were collected on clinical OA at any site (hand, knee or hip), based on the clinical
classification criteria developed by the American College of Rheumatology (ACR). Frailty was defined according
to Fried's criteria. The covariates considered were age, gender, educational level, obesity and country. We used
multinomial logistic regression to analyse the associations between OA, frailty/pre-frailty and other covariates.
Results: The overall prevalence of clinical OA at any site was 30.4 % (95 % CI:28.6-32.2); frailty was present in 10.2 %
(95 % CI:9.0-11.4) and pre-frailty in 51.0 % (95 % CI:49.0-53.0). The odds of frailty was 2.96 (95 % CI:2.11-4.16)
and pre-frailty 1.54 (95 % CI:1.24-1.91) as high among OA individuals than those without OA. The association
remained when Knee OA, hip OA or hand OA were considered separately, and was stronger in those with
increasing number of joints.
Conclusions: Clinical OA is associated with frailty and pre-frailty in older adults in European countries. This
association might be considered when designing appropriate intervention strategies for OA management
Files in this item
Google Scholar:Castell Alcalá, María Victoria
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Van Der Pas, Suzan
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Otero, Angel
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Siviero, Paola
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Dennison, Elaine
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Denkinger, Michael
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Pedersen, Nancy Lee
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Sánchez Martínez, Mercedes
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Queipo, Rocio
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Van Schoor, Natasja
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Zambon, Sabina
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Edwards, Mark
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Peter, Richard
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Schaap, Laura
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Deeg, Dorly
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