Osteoarthritis and frailty in elderly individuals across six European countries: Results from the European Project on OSteoArthritis (EPOSA)

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dc.contributor.author Castell, María Victoria
dc.contributor.author Van Der Pas, Suzan
dc.contributor.author Otero, Angel
dc.contributor.author Siviero, Paola
dc.contributor.author Dennison, Elaine
dc.contributor.author Denkinger, Michael
dc.contributor.author Pedersen, Nancy Lee
dc.contributor.author Sánchez Martínez, Mercedes
dc.contributor.author Queipo, Rocio
dc.contributor.author Van Schoor, Natasja
dc.contributor.author Zambon, Sabina
dc.contributor.author Edwards, Mark
dc.contributor.author Peter, Richard
dc.contributor.author Schaap, Laura
dc.contributor.author Deeg, Dorly
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) es_ES
dc.date.accessioned 2016-07-27T12:47:33Z
dc.date.available 2016-07-27T12:47:33Z
dc.date.issued 2015-11-17
dc.identifier.citation BMC Musculoskeletal Disorders 16.1 (2015): 359 en_US
dc.identifier.issn 1471-2474 es_ES
dc.identifier.uri http://hdl.handle.net/10486/672258
dc.description.abstract Background: Osteoarthritis (OA) is the most common cause of disability in the elderly. Clinical frailty is associated with high mortality, but few studies have explored the relationship between OA and frailty. The objective of this study was to consider the association between OA and frailty/pre-frailty in an elderly population comprised of six European cohorts participating in the EPOSA project. Methods: Longitudinal study using baseline data and first follow-up waves, from EPOSA; 2,455 individuals aged 65-85 years were recruited from pre-existing population-based cohorts in Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom. Data were collected on clinical OA at any site (hand, knee or hip), based on the clinical classification criteria developed by the American College of Rheumatology (ACR). Frailty was defined according to Fried's criteria. The covariates considered were age, gender, educational level, obesity and country. We used multinomial logistic regression to analyse the associations between OA, frailty/pre-frailty and other covariates. Results: The overall prevalence of clinical OA at any site was 30.4 % (95 % CI:28.6-32.2); frailty was present in 10.2 % (95 % CI:9.0-11.4) and pre-frailty in 51.0 % (95 % CI:49.0-53.0). The odds of frailty was 2.96 (95 % CI:2.11-4.16) and pre-frailty 1.54 (95 % CI:1.24-1.91) as high among OA individuals than those without OA. The association remained when Knee OA, hip OA or hand OA were considered separately, and was stronger in those with increasing number of joints. Conclusions: Clinical OA is associated with frailty and pre-frailty in older adults in European countries. This association might be considered when designing appropriate intervention strategies for OA management en_US
dc.description.sponsorship The study was supported by a non-commercial private funder. The Indicators for Monitoring COPD and Asthma - Activity and Function in the Elderly in Ulm study (IMCA - ActiFE) was supported by the European Union (No.: 2005121) and the Ministry of Science, Baden-Württemberg. The Italian cohort study is part of the National Research Council Project on Aging (PNR). The Longitudinal Aging Study Amsterdam (LASA) is financially supported by the Dutch Ministry of Health, Welfare and Sports. The Peñagrande study was partially supported by the National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain (project numbers FIS PI 05/1898; FIS RETICEF RD06/0013/1013 and FIS PS09/02143). The Swedish Twin Registry is supported in part by the Swedish Ministry of Higher Education. The Hertfordshire Cohort Study is funded by the Medical Research Council of Great Britain, Arthritis Research UK, the British Heart Foundation and the International Osteoporosis Foundation. en_US
dc.format.extent 8 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher BioMed Central es_ES
dc.relation.ispartof BMC Musculoskeletal Disorders en_US
dc.rights © 2015 Castell et al. en_US
dc.subject.other European en_US
dc.subject.other Older people en_US
dc.subject.other Osteoarthritis en_US
dc.subject.other Frailty en_US
dc.subject.other Prevalence en_US
dc.title Osteoarthritis and frailty in elderly individuals across six European countries: Results from the European Project on OSteoArthritis (EPOSA) es_ES
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/s12891-015-0807-8 es_ES
dc.identifier.doi 10.1186/s12891-015-0807-8 es_ES
dc.identifier.publicationfirstpage 359 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 359 es_ES
dc.identifier.publicationvolume 16 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/2005121 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en_US
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Castell Alcala, María Victoria (261302)
dc.authorUAM Sánchez Martínez, Mercedes (262259)


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