Polymorphisms associated with age at onset in patients with moderate-to-severe plaque psoriasis

Abstract

Psoriasis is a chronic skin disease in which genetics play a major role. Although many genome-wide association studies have been performed in psoriasis, knowledge of the age at onset remains limited. Therefore, we analyzed 173 single-nucleotide polymorphisms in genes associatedwith psoriasis and other autoimmune diseases in patients with moderate-to-severe plaque psoriasis type I (earlyonset, <40 years) or type II (late-onset, ≥40 years) and healthy controls. Moreover, we performed a comparison between patients with type I psoriasis and patients with type II psoriasis. Our comparison of a stratified population with type I psoriasis (𝑛 = 155) and healthy controls (𝑁 = 197) is the first to reveal a relationship between the CLMN, FBXL19, CCL4L, C17orf51, TYK2, IL13, SLC22A4, CDKAL1, and HLA-B/MICA genes. When we compared type I psoriasis with type II psoriasis (𝑁= 36), we found a significant association between age at onset and the genes PSORS6, TNF-𝛼, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1.Moreover, we replicated the association between rs12191877 (HLA-C) and type I psoriasis and between type I and type II psoriasis. Our findings highlight the role of genetics in age of onset of psoriasis