Prognostic value of the six-second spirometry in patients with chronic obstructive pulmonary disease: A cohort study

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dc.contributor.author Prats, Eva
dc.contributor.author Tejero, Elena
dc.contributor.author Pardo, Paloma
dc.contributor.author Gavilán, Adelaida
dc.contributor.author Galera, Raúl
dc.contributor.author Donano, José Ramón
dc.contributor.author Racionero, Miguel Ángel
dc.contributor.author Casitas, Raquel
dc.contributor.author Zapatero, Antonio
dc.contributor.author García-Rico, Francisco
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) es_ES
dc.date.accessioned 2016-07-28T13:09:46Z
dc.date.available 2016-07-28T13:09:46Z
dc.date.issued 2015-10-21
dc.identifier.citation PLos ONE 10.10 (2015): e0140855 en_US
dc.identifier.issn 1932-6203 es_ES
dc.identifier.uri http://hdl.handle.net/10486/672289
dc.description.abstract Background The six-second spirometry has been proposed as an alternative to diagnose airflow limitation, although its prognostic value in patients with chronic obstructive pulmonary disease (COPD) remains unknown. The purpose of this study was to determine the prognostic value of the postbronchodilator forced expiratory volume in 1 second (FEV1)/forced expiratory volume in 6 seconds (FEV6) ratio and FEV6 in COPD patients. Methods and Findings The study population consisted of 2,614 consecutive stable patients with COPD. The patients were monitored for an average period of 4.3 years regarding mortality, hospitalizations by COPD exacerbations, diagnosis of lung cancer, and annual lung function decline. The overall rate of death was 10.7 (95%CI: 8.7–12.7) per 1000 person-years. In addition to male gender, age and comorbidity, FEV6 (hazard ratio [HR]: 0.981, 95%CI: 0.968–0.003) and FEV1/FEV6 quartiles (lowest quartile (<74% pred.): HR 3.558, 95%CI: 1.752–7.224; and second quartile (74–84% pred.): HR 2.599, 95%CI: 1.215–5.561; versus best quartile (>0.89% pred.)) were independently associated with mortality, whereas FEV1 was not retained in the model. 809 patients (30.9%) had at least one hospital admission due to COPD exacerbation. In addition to sex, age, smoking and comorbidity, FEV1 and FEV1/ FEV6 quartiles were independent risk factors of hospitalization. FEV6 was the only spirometric parameter independently related with lung function annual decline, while the FEV6 and FEV1/FEV6 quartiles were independent risk factors for lung cancer Conclusions In a general COPD outpatient population, airflow obstruction assessed by the FEV1/FEV6 is an independent risk factor for both death and hospitalization en_US
dc.description.sponsorship This study is supported by grants from the Instituto de Salud Carlos III, Spain (PI10-00642 and PI13-01512) and from the Comunidad de Madrid, Spain (S2010/BMD-2542). en_US
dc.format.extent 16 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Public Library of Science en_US
dc.relation.ispartof PLoS ONE en_US
dc.rights © 2015 Prats et al. es_ES
dc.subject.other Prognostic value en_US
dc.subject.other Patients en_US
dc.subject.other Obstructive pulmonary disease en_US
dc.title Prognostic value of the six-second spirometry in patients with chronic obstructive pulmonary disease: A cohort study en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1371/journal.pone.0140855 es_ES
dc.identifier.doi 10.1371/journal.pone.0140855 es_ES
dc.identifier.publicationfirstpage e0140855 es_ES
dc.identifier.publicationissue 10 es_ES
dc.identifier.publicationlastpage e0140855 es_ES
dc.identifier.publicationvolume 10 es_ES
dc.relation.projectID Comunidad de Madrid. S2010/BMD-2542/CONSEPOC es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en


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