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Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: A case-only study
Author
Montes, Ariana; Pérez-Pampin, Eva; Navarro-Sarabia, Federico; Moreira, Virginia; Rodríguez de la Serna, Arturo; Magallares, Berta; Vasilopoulos, Yiannis; Sarafidou, Theologia; Fernández-Nebro, Antonio; Ordóñez, María del Carmen; Narváez, Javier; Cañete, Juan D.; Márquez, Ana; Pascual-Salcedo, Dora; Joven, Beatriz; Carreira, Patricia; Moreno-Ramos, Manuel J.; Caliz, Rafael; Ferrer, Miguel Ángel; GarcÍa-Portales, Rosa; Blanco, Francisco J.; Magro, Cesar; Raya, Enrique; Valor, Lara; Alegre-Sancho, Juan J.; Balsa Criado, Alejandro; Martín, Javier; Plant, Darren; Isaacs, John; Morgan, Ann W.; Barton, Anne; Wilson, Anthony G.; Gómez-Reino, Juan J.; González, AntonioEntity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
BioMed CentralDate
2015-03-18Citation
10.1186/s13075-015-0571-z
Arthritis Research and Therapy 17.1 (2015): 63
ISSN
1478-6354 (print); 1478-6362 (online)DOI
10.1186/s13075-015-0571-zFunded by
Funding was provided by grants PI11/01048, PI12/01909 and by RETICS Program, RD08/0075/0019 and RD12/0009/0008 (RIER) of the Instituto de Salud Carlos III (Spain) that are partially financed by the European Regional Development Fund of the European Union.Editor's Version
http://dx.doi.org/10.1186/s13075-015-0571-zSubjects
Rheumatoid arthritis; Treatment; IgG1 allotype; MedicinaRights
© 2015 Montes et al.Abstract
Introduction: We have hypothesized that incompatibility between the G1m genotype of the patient and the
G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of
these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA).
Methods: The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects.
The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for
replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two
outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League
Against Rheumatism (EULAR) response criteria.
Results: An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the
discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02
and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4
units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible
patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03).
A similar association was suggested for patients treated with ADM in the discovery collection, but it was not
supported by replication.
Conclusions: Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid
improved therapeutic targeting in RA
Files in this item
Google Scholar:Montes, Ariana
-
Pérez-Pampin, Eva
-
Navarro-Sarabia, Federico
-
Moreira, Virginia
-
Rodríguez de la Serna, Arturo
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Magallares, Berta
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Vasilopoulos, Yiannis
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Sarafidou, Theologia
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Fernández-Nebro, Antonio
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Ordóñez, María del Carmen
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Narváez, Javier
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Cañete, Juan D.
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Márquez, Ana
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Pascual-Salcedo, Dora
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Joven, Beatriz
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Carreira, Patricia
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Moreno-Ramos, Manuel J.
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Caliz, Rafael
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Ferrer, Miguel Ángel
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GarcÍa-Portales, Rosa
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Blanco, Francisco J.
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Magro, Cesar
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Raya, Enrique
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Valor, Lara
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Alegre-Sancho, Juan J.
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Balsa Criado, Alejandro
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Martín, Javier
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Plant, Darren
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Isaacs, John
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Morgan, Ann W.
-
Barton, Anne
-
Wilson, Anthony G.
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Gómez-Reino, Juan J.
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González, Antonio
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